Study on quantitative evaluation of respiratory-induced organ motion and high-precision particle cancer therapy

为了对具有呼吸运动的肺癌进行高精度的放射/粒子治疗，已经使用CT图像研究了肺运动评估技术。研究了真实感CT图像中影响运动跟踪精度的肺区域和血管的提取方法，抑制了对肺边界和血管不必要的精细结构提取。为实现肺肿瘤的高精度治疗，对重离子治疗的呼吸门控照射进行了验证。重点研究了重离子治疗计划系统中运动误差和裕度的评价以及裕度的处理方法。该方法的有效性已通过运动体模的束流测试得到验证。

Lung motion evaluation techniques have been studied using CT images in order to make highly precise radiation/particle therapy for lung cancer with respiratory motion. The extraction methods of lung areas and vessels with realistic CT images, which would influence on the motion tracking accuracy, have been investigated, and the unnecessarily fine structure extraction of lung borders and vessels could be suppressed. Verification on respiratory gated-irradiation of heavy-ion therapy for lung tumors has been carried out to realize the high-precision therapy. Particularly, investigations have been carried out on evaluation of motion errors and margins, and how to deal with the margins in heavy-ion treatment planning system. The validity has been verified by beam tests with a motion phantom.