The ^<17>O MRS/MRI for the tumor oxygen consumption rate in mice

小鼠肿瘤耗氧率^ 17 O MRS/MRI

• 批准号: 20790893
• 负责人: NARAZAKI Michiko
• 金额: $ 2.16万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790893/
• 关键词: 核磁気共鳴画像(MRI); 多核種; 酸素代謝

The tumor oxygen consumption rate in tumor-bearing mice using ^<17>O MRS/MRI was investigated based on the metabolically generated ^<17>O-water from ^<17>O2 gas. ^<17>O images were acquired before and after the inhalation of ^<17>O enriched oxygen gas. The increment in the ^<17>O image intensity due to the metabolically generated H2^<17>O from ^<17>O2 was converted to the quantity of produced H2^<17>O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.

利用~&lt；17&gt；O2气体代谢产生的~&lt；17&gt；O-水，用~&lt；17&gt；O MRS/MRI研究了荷瘤小鼠的肿瘤耗氧速率。分别在吸入富氧气体前后采集图像。将代谢产生的H2^&lt；17&gt；O的图像强度增量转化为H2^&lt；17&gt；O的生成量，这与文献中的生理数据吻合较好。我们证实这种方法有望成为监测肿瘤耗氧率的一种工具。

项目成果

The 17O imaging for regional oxygen consumption rate in tumor bearing mice at 7T.

7T 荷瘤小鼠局部耗氧率的 17O 成像。

• 发表时间: 2010
• 作者: 天満敬;ほか;Michiko Narazaki
• 通讯作者: Michiko Narazaki