The ^<17>O MRS/MRI for the tumor oxygen consumption rate in mice

基于由^O 2气体代谢产生的^O-水，使用^ O MRS/MRI研究荷瘤小鼠中的肿瘤耗氧速率<17><17><17>。在<17>吸入富氧气体之前和之后获得120图像<17>。由<17>^ O2代谢产生的H2^ O引起的^ O图像强度<17>的增加<17>被转换为产生的H2 ^ O的量<17>，这与文献中的生理数据非常一致。我们证实了这种方法作为监测肿瘤耗氧率的工具是有前途的。

The tumor oxygen consumption rate in tumor-bearing mice using ^<17>O MRS/MRI was investigated based on the metabolically generated ^<17>O-water from ^<17>O2 gas. ^<17>O images were acquired before and after the inhalation of ^<17>O enriched oxygen gas. The increment in the ^<17>O image intensity due to the metabolically generated H2^<17>O from ^<17>O2 was converted to the quantity of produced H2^<17>O, which was in good agreement with physiological data in literature. We confirmed this method promising as a tool for monitoring the oxygen consumption rate in tumor.