Metabolic imaging using fluorinated hexoses in tumor bearing mouse by 19F MRS/MRI

利用2-脱氧-2-氟-d -葡萄糖（FDG）的19F MRS/MRI作为肿瘤特征性诊断的定量成像方法进行了探讨。在肿瘤位置0处获得19FDG代谢图像。注射FDG后5、3、24、48小时。成像后切除的肿瘤组织和器官中的代谢物被量化，并通过19F NMR作为水提取物进行详细分析。在切除组织中，FDG代谢物长时间以高浓度保留。19F MRS/MRI被证明是一种很好的肿瘤表征方法，反映了代谢特异性。

19F MRS/MRI using 2-deoxy-2-fluoro-D-glucose(FDG) was explored as a method for quantitative imaging towards characteristic diagnosis of tumor. 19FDG metabolic images were obtained at the tumor position at 0. 5, 3, 24, 48 hour after FDG injection. Metabolites were quantified in tumor tissue and organs excised after the imaging, and the detailed analysis was performed as water extracts by 19F NMR. In the excised tissue, FDG metabolites were retained for a long time at the high concentration. 19F MRS/MRI was shown to be an excellent method for tumor characterization reflecting metabolic specificity.