Metabolic imaging using fluorinated hexoses in tumor bearing mouse by 19F MRS/MRI

通过 19F MRS/MRI 使用氟化己糖对荷瘤小鼠进行代谢成像

• 批准号: 22791186
• 负责人: NARAZAKI Michiko
• 金额: $ 1.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791186/
• 关键词: 核磁気共鳴画像(MRI); 多核種; 19F; 代謝物画像; 腫瘍; 核磁気共鳴(MRI); MRスペクトロスコピー(MRS); 糖代謝; 担がんマウス

19F MRS/MRI using 2-deoxy-2-fluoro-D-glucose(FDG) was explored as a method for quantitative imaging towards characteristic diagnosis of tumor. 19FDG metabolic images were obtained at the tumor position at 0. 5, 3, 24, 48 hour after FDG injection. Metabolites were quantified in tumor tissue and organs excised after the imaging, and the detailed analysis was performed as water extracts by 19F NMR. In the excised tissue, FDG metabolites were retained for a long time at the high concentration. 19F MRS/MRI was shown to be an excellent method for tumor characterization reflecting metabolic specificity.

本文探讨了19 F-MRS/MRI（2-脱氧-2-氟-D-葡萄糖）定量成像对肿瘤特征性诊断的价值。19 FDG代谢显像于肿瘤部位0.注射FDG后5、3、24、48小时。在成像后切除的肿瘤组织和器官中定量甲硫氨酸，并通过19 F NMR作为水提取物进行详细分析。在切除的组织中，FDG代谢产物以高浓度保留较长时间。19 F MRS/MRI被证明是反映代谢特异性的肿瘤表征的极好方法。

项目成果

Systematic Study of Protein Detection Mechanism of Self-Assembling 19F NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity

• DOI: 10.1021/ja203996c
• 发表时间: 2011-08-03
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Takaoka, Yousuke;Kiminami, Keishi;Hamachi, Itaru
• 通讯作者: Hamachi, Itaru

A pre-targeting Strategy for MR Imaging of Functional Molecules Using Dendritic Gd-Based Contrast Agents

使用基于树枝状钆的造影剂对功能分子进行 MR 成像的预靶向策略

• 发表时间: 2011
• 期刊: Molecular Imaging and Biology
• 影响因子: 3.1
• 作者: K Sano;T Temma;T Azuma;R Nakai;M Narazaki;Y Kuge;H Saji
• 通讯作者: H Saji

Turn-on型蛋白質検出^<19>F MRIプローブの検出メカニズム解明と高感度化

启动蛋白检测^<19>F 阐明MRI探针的检测机制并提高灵敏度

• 发表时间: 2011
• 作者: 高岡洋輔;木南啓司;水澤圭吾;松尾和哉;楢崎美智子;松田哲也;浜地格
• 通讯作者: 浜地格

抗HER2ペプチドを導入した新規デンドリマーアミン配位Gd-MRI造影剤の合成と機能評価

新型树枝状胺配位抗 HER2 肽 Gd-MRI 造影剂的合成及功能评价

• 发表时间: 2011
• 作者: 木村祐;雉鳥弘樹;三宅由花;楢崎美智子;松田哲也;矢野哲哉;近藤輝幸
• 通讯作者: 近藤輝幸

Fluorinated Polymer Nanoparticles as a Novel ^<19>F MRI Contrast Agent Prepared by Dendrimer-Initiated Living Radical Polymerization

通过树枝状聚合物引发的活性自由基聚合制备氟化聚合物纳米粒子作为新型^ 19 F MRI造影剂

• 发表时间: 2010
• 期刊: Macromolecular Chemistry and Physics
• 影响因子: 2.5
• 作者: Michihiro Ogawa;Satoshi Nitahara;Hiroyuki Aoki;Shinzaburo Ito;Michiko Narazaki;Tetsuya Matsuda
• 通讯作者: Tetsuya Matsuda