Visualization of microscopic structure and cell membrane function based on diffusion of water molecule in biological tissue

基于生物组织中水分子扩散的微观结构和细胞膜功能可视化

• 批准号: 20790884
• 负责人: IMAE Toshikazu
• 金额: $ 1.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790884/
• 关键词: MRI; 拡散; 生体内水分子; 細胞膜機能; 可視化; 細胞膜透過率; ラット; ヒト; 有限差分法; 非侵襲

The signal intensity of diffusion-weighted imaging is sensitive to the intra- and extracellular diffusion coefficient of water and cell membrane permeability. We proposed a method to estimate noninvasively the membrane permeability and intracellular diffusion coefficient. The estimated membrane permeability of normal human brain and infarcted rat brain were 76±9μm/sec and 58μm/sec, respectively. The result indicates that injury due to the cerebral infarction causes the decline of the cell membrane function.

扩散加权成像的信号强度对水的细胞内外扩散系数和细胞膜通透性敏感。我们提出了一种无创估计膜通透性和细胞内扩散系数的方法。正常人脑和脑梗塞大鼠的膜通透性分别为76±9μm/s和58μm/s。结果表明，脑梗塞所致损伤可导致细胞膜功能下降。

项目成果

拡散MRIを用いた脳梗塞ラットの細胞膜透過率評価.

使用扩散MRI评估脑梗死大鼠细胞膜通透性。

• 发表时间: 2009
• 作者: 今江禄一;篠原広行;関野正樹;上野照剛;大崎博之;美馬和男
• 通讯作者: 美馬和男

Minimization of Computational Errors in Diffusion Simulation of Nuclear Magnetization

核磁化扩散模拟中计算误差的最小化

• 发表时间: 2008
• 期刊: IEEE Transactions on Magnetics 44
• 作者: Lu M;Ueno S;Thorlin T;Persson M.;Sachiko Yamaguchi-Sekino;Toshikazu Imae
• 通讯作者: Toshikazu Imae

Estimation of Cell Membrane Permeability and Intracellular Diffusion Coefficient of Human Gray Matter

• DOI: 10.2463/mrms.8.1
• 发表时间: 2009-01-01
• 期刊: MAGNETIC RESONANCE IN MEDICAL SCIENCES
• 影响因子: 3
• 作者: Imae, Toshikazu;Shinohara, Hiroyuki;Ohtomo, Kuni
• 通讯作者: Ohtomo, Kuni

Minimization of computational errors in 1D diffusion simulation of nuclear magnetization

核磁化一维扩散模拟中计算误差的最小化

• 发表时间: 2009
• 期刊: IEEE Transactions on Magnetics 22
• 作者: T.Imae;et.al.
• 通讯作者: et.al.

Estimation of cell membrane permeability and intracellular diffusion coefficient of the gray matter in the normal human brain

正常人脑灰质细胞膜通透性和细胞内扩散系数的估计

• 发表时间: 2009
• 作者: T.Imae;et al.
• 通讯作者: et al.