Visualization of microscopic structure and cell membrane function based on diffusion of water molecule in biological tissue

扩散加权成像的信号强度对水的细胞内外扩散系数和细胞膜通透性敏感。我们提出了一种无创估计膜通透性和细胞内扩散系数的方法。正常人脑和脑梗塞大鼠的膜通透性分别为76±9μm/s和58μm/s。结果表明，脑梗塞所致损伤可导致细胞膜功能下降。

The signal intensity of diffusion-weighted imaging is sensitive to the intra- and extracellular diffusion coefficient of water and cell membrane permeability. We proposed a method to estimate noninvasively the membrane permeability and intracellular diffusion coefficient. The estimated membrane permeability of normal human brain and infarcted rat brain were 76±9μm/sec and 58μm/sec, respectively. The result indicates that injury due to the cerebral infarction causes the decline of the cell membrane function.