Combined <11>^C-Choline PET with high-resolution MRI : Development for T- and N-Stage Assessment in Patients with Prostate Cancer.

我们评估了联合使用β-<11>C-胆碱PET和CT或MRI对因活检证实的前列腺癌而进行根治性前列腺切除术的候选人进行T期和N期评估的初步结果。34例病理诊断的前列腺癌患者在手术切除前前瞻性接受<11>了13 C-胆碱PET、非增强全身MDCT和盆腔MRI。然后，由一名经委员会认证的放射科医生和一名核医学医生在联合PET与CT或MRI（联合PET-CT/MRI）上评估每例患者的T分期和N分期，并由两名阅片人达成共识对每例患者进行最终诊断。当评价所有图像时，读片者不知道任何临床信息和组织学结果。然后，将每个患者的评估T-和N-分期与基于病理结果的每个T-和N-分期进行比较，并确定诊断倾向。32例患者行根治性盆腔切除术，2例患者因盆腔淋巴结转移而行剖腹探查术。术后T分期为pT 2b（n=13）、pT 3a（n=8）、pT 3b（n=1）和pT 4（n=10）。在T分期评估中，PET-CT/MRI联合方法可以正确诊断所有pT 2b和pT 3a患者，而该方法不能正确诊断pT 3b和pT 4患者。在N期评估中，所有短轴直径大于7 mm的淋巴结转移均在PET-CT/MRI联合检查中得到正确诊断。我们的初步结果表明，联合PET-CT/MRI可能是有用的T和N期评估前列腺癌患者。我们在第12届亚洲大洋洲放射学大会上发表了这一成果<th>。需要进一步的研究来阐明这种方法的有用性。

We evaluated the preliminary result of combined <11>^C-choline PET and CT or MRI for T- and N-stage assessments in candidates for radical prostatectomy due to biopsy-proven prostatic cancer. Thirty-four pathologically diagnosed prostate cancer patients prospectively underwent <11>^C-choline PET, unenhanced whole-body MDCT and pelvic MRI prior to surgical resection. Then, a board-certified radiologist and a nuclear medicine physician assessed T- and N-stage in each patient on combined PET with CT or MRI (combined PET-CT/MRI), and final diagnosis in each patient was made by consensus of two readers. When all images were evaluated, readers were unaware of any clinical information and histological results. Then, assessed T- and N-stage in each patient were compared with each T- and N-stages based on pathological results, and diagnostic tendency were determined. Thirty-two cases underwent radical prostatectomies, and two cases were underwent exploratory laparotomies due to a detection of pelvic lymph nodes metastases. Postoperative T staging were pT2b (n=13), pT3a (n=8), pT3b (n=1), and pT4 (n=10). On T-stage assessment, combined PET-CT/MRI could correctly diagnose in all patients with pT2b and pT3a, whereas this method could not correctly diagnose in patients with pT3b and pT4. On N-stage assessment, all lymph node metastases, whose short axis diameters were more than 7mm, were correctly diagnosed on combined PET-CT/MRI. Our preliminary result suggests that combined PET-CT/MRI might be useful for T- and N-stage assessments in patients with prostatic cancer. We presented the result on 12^<th> Asian Oceanian Congress of Radiology. Further studies are needed to clarify the usefulness of this method.