Combined <11>^C-Choline PET with high-resolution MRI : Development for T- and N-Stage Assessment in Patients with Prostate Cancer.

我们评估了联合&lt；11&gt；、C-胆碱PET和CT或MRI对因活检证实的前列腺癌而行前列腺癌根治术的候选人进行T和N分期评估的初步结果。34例经病理确诊的前列腺癌患者在手术切除前前瞻性地接受了C-胆碱PET、平扫全身多层螺旋CT和盆腔MRI检查。然后，一名委员会认证的放射科医生和一名核医学医生对每个患者进行了联合PET和CT或MRI(联合PET-CT/MRI)的T期和N期评估，并通过两位读者的共识做出了最终诊断。当对所有图像进行评估时，读者不知道任何临床信息和组织学结果。然后根据病理结果，将每例患者的T、N分期与各T、N分期进行比较，确定诊断倾向。32例行前列腺癌根治术，2例行剖腹探查发现盆腔淋巴结转移。术后T分期：pT2b 13例，pT3a 8例，pT3b 1例，pT4 10例。在T分期评估上，联合应用PET-CT/MRI对所有pT2b和pT3a患者均能作出正确诊断，而对pT3b和PT4患者不能作出正确诊断。在N分期评估中，所有短轴直径大于7 mm的淋巴结转移均在联合PET-CT/MRI上被正确诊断。我们的初步结果表明，PET-CT/MRI联合检查对前列腺癌患者的T和N分期评估可能是有用的。我们在第12届亚洲大洋洲放射学大会上公布了这一结果。还需要进一步的研究来阐明这种方法的有效性。

We evaluated the preliminary result of combined <11>^C-choline PET and CT or MRI for T- and N-stage assessments in candidates for radical prostatectomy due to biopsy-proven prostatic cancer. Thirty-four pathologically diagnosed prostate cancer patients prospectively underwent <11>^C-choline PET, unenhanced whole-body MDCT and pelvic MRI prior to surgical resection. Then, a board-certified radiologist and a nuclear medicine physician assessed T- and N-stage in each patient on combined PET with CT or MRI (combined PET-CT/MRI), and final diagnosis in each patient was made by consensus of two readers. When all images were evaluated, readers were unaware of any clinical information and histological results. Then, assessed T- and N-stage in each patient were compared with each T- and N-stages based on pathological results, and diagnostic tendency were determined. Thirty-two cases underwent radical prostatectomies, and two cases were underwent exploratory laparotomies due to a detection of pelvic lymph nodes metastases. Postoperative T staging were pT2b (n=13), pT3a (n=8), pT3b (n=1), and pT4 (n=10). On T-stage assessment, combined PET-CT/MRI could correctly diagnose in all patients with pT2b and pT3a, whereas this method could not correctly diagnose in patients with pT3b and pT4. On N-stage assessment, all lymph node metastases, whose short axis diameters were more than 7mm, were correctly diagnosed on combined PET-CT/MRI. Our preliminary result suggests that combined PET-CT/MRI might be useful for T- and N-stage assessments in patients with prostatic cancer. We presented the result on 12^<th> Asian Oceanian Congress of Radiology. Further studies are needed to clarify the usefulness of this method.