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Combined <11>^C-Choline PET with high-resolution MRI : Development for T- and N-Stage Assessment in Patients with Prostate Cancer.

11C-胆碱 PET 与高分辨率 MRI 相结合：前列腺癌患者 T 期和 N 期评估的开发。

基本信息

批准号：
20790897
负责人：
MAEDA Tetsuo
金额：
$ 2.75万
依托单位：
Kobe University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2009
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790897/
关键词：
前立腺がんコリンPET MRI

项目摘要

We evaluated the preliminary result of combined <11>^C-choline PET and CT or MRI for T- and N-stage assessments in candidates for radical prostatectomy due to biopsy-proven prostatic cancer. Thirty-four pathologically diagnosed prostate cancer patients prospectively underwent <11>^C-choline PET, unenhanced whole-body MDCT and pelvic MRI prior to surgical resection. Then, a board-certified radiologist and a nuclear medicine physician assessed T- and N-stage in each patient on combined PET with CT or MRI (combined PET-CT/MRI), and final diagnosis in each patient was made by consensus of two readers. When all images were evaluated, readers were unaware of any clinical information and histological results. Then, assessed T- and N-stage in each patient were compared with each T- and N-stages based on pathological results, and diagnostic tendency were determined. Thirty-two cases underwent radical prostatectomies, and two cases were underwent exploratory laparotomies due to a detection of pelvic lymph nodes metastases. Postoperative T staging were pT2b (n=13), pT3a (n=8), pT3b (n=1), and pT4 (n=10). On T-stage assessment, combined PET-CT/MRI could correctly diagnose in all patients with pT2b and pT3a, whereas this method could not correctly diagnose in patients with pT3b and pT4. On N-stage assessment, all lymph node metastases, whose short axis diameters were more than 7mm, were correctly diagnosed on combined PET-CT/MRI. Our preliminary result suggests that combined PET-CT/MRI might be useful for T- and N-stage assessments in patients with prostatic cancer. We presented the result on 12^<th> Asian Oceanian Congress of Radiology. Further studies are needed to clarify the usefulness of this method.

我们评估了组合 11 C-胆碱 PET 和 CT 或 MRI 对因活检证实的前列腺癌而接受根治性前列腺切除术的候选者进行 T 期和 N 期评估的初步结果。 34名经病理诊断的前列腺癌患者在手术切除前前瞻性地接受了11 C-胆碱PET、非增强全身MDCT和盆腔MRI。然后，一名经过委员会认证的放射科医生和一名核医学医师通过 PET 与 CT 或 MRI 联合（组合 PET-CT/MRI）评估每位患者的 T 期和 N 期，并由两名读者一致同意对每位患者进行最终诊断。当评估所有图像时，读者不知道任何临床信息和组织学结果。然后，将每位患者评估的T期和N期与病理结果的每个T期和N期进行比较，并确定诊断倾向。 32例接受前列腺根治术，2例因发现盆腔淋巴结转移而接受剖腹探查术。术后T分期为pT2b（n=13）、pT3a（n=8）、pT3b（n=1）和pT4（n=10）。在T分期评估中，联合PET-CT/MRI可以正确诊断所有pT2b和pT3a患者，而该方法不能正确诊断pT3b和pT4患者。 N期评估中，PET-CT/MRI联合诊断所有短轴直径大于7mm的淋巴结转移灶均被正确诊断。我们的初步结果表明，联合 PET-CT/MRI 可能有助于前列腺癌患者的 T 期和 N 期评估。我们在第十二届亚洲大洋洲放射学大会上公布了结果。需要进一步的研究来阐明该方法的有用性。