Comprehensive analysis of hematopoietic stem cell-specific genes

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The aim of this study is to clarify meanings of endothelial cell-specific adhesion molecule-1 (ESAM-1) in hematopoietic stem cell biology. Expression of ESAM-1 was up-regulated when hematopoietic stem cells went into proliferation state. In ESAM-1-deficient mice, they died after 5-FU treatment by severe anemia. We found that ESAM-1 was required for early differentiation of red blood cells.Although human hematopoietic stem cells expressed ESAM-1, we found a highly ESAM-1-expressing population in cord blood cells. They had an ability to differentiate into endotherial cells, thereby indicating as a new source of cell-based therapy.