The study about the early diagnostic method of dementia with Lewy bodies

本研究的目的是建立路易体痴呆的早期诊断方法，它是仅次于阿尔茨海默病的第二种最常见的退行性痴呆类型。我们比较了脑灌注SPECT、123&GT；I-MIBG心肌显像三种方法的诊断价值，并将脑MRI纳入DLB标准。MIBG对DLB与AD鉴别诊断的敏感性和特异度明显高于其他方法，因此，MIBG显像在鉴别DLB与AD方面可能优于脑显像，有望成为临床早期发现DLB最可靠的方法。

The aim of this study is to establish early diagnostic method of dementia of Lewy bodies (DLB) which is the second most common type of degenerative dementia next to Alzheimer's disease (AD). We compared the diagnostic value of three methods which were brain perfusion SPECT, ^<123>I-MIBG myocardial scintigraphy, and brain MRI included the criteria of DLB. The sensitivity and specificity of MIBG study in differentiation DLB from AD were very higher than other methods, so it was expected that MIBG scintigraphy could be superior to brain imaging for distinguishing between DLB and AD, and that might be the most reliable procedure of detecting DLB in early clinical stage.