The study about the early diagnostic method of dementia with Lewy bodies

路易体痴呆（DLB）是仅次于阿尔茨海默病（AD）的第二常见的退行性痴呆类型，本研究旨在建立路易体痴呆的早期诊断方法。比较脑灌注SPECT、^<123>I-MIBG心肌显像和脑MRI对DLB的诊断价值。MIBG研究鉴别DLB与AD的敏感性和特异性均远高于其他方法，因此MIBG显像鉴别DLB与AD的效果有望优于脑成像，可能是临床早期检测DLB最可靠的方法。

The aim of this study is to establish early diagnostic method of dementia of Lewy bodies (DLB) which is the second most common type of degenerative dementia next to Alzheimer's disease (AD). We compared the diagnostic value of three methods which were brain perfusion SPECT, ^<123>I-MIBG myocardial scintigraphy, and brain MRI included the criteria of DLB. The sensitivity and specificity of MIBG study in differentiation DLB from AD were very higher than other methods, so it was expected that MIBG scintigraphy could be superior to brain imaging for distinguishing between DLB and AD, and that might be the most reliable procedure of detecting DLB in early clinical stage.