Development of a radioprobe for quantifying the activity of multidrug resistance protein

开发用于定量多药耐药蛋白活性的放射性探针

• 批准号: 20790924
• 负责人: KIKUCHI Tatsuya
• 金额: $ 2.58万
• 依托单位: National Institute of Radiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790924/
• 关键词: 多剤耐性タンパク質; 放射性プローブ; PET; 脳

The aim of this study is to develop a radioprobe for quantifying the activity of multidrug resistance protein. The in vivo measurement of P-glycoprotein activity would be useful for development of drugs and optimizing the dose, whereas the method has not been established. In this study, we evaluated the compound, which was considered to be a substrate for P-glycoprotein, to achieve the aim. However, the extraction of the compounds from the brain was considered to be mediated by the other unknown transporters.

本研究的目的是研制一种用于多药耐药蛋白活性定量的放射探针。P-糖蛋白活性的体内测定将有助于药物的开发和剂量的优化，而方法尚未建立。在这项研究中，我们评估的化合物，这被认为是一个底物的P-糖蛋白，以实现这一目标。然而，认为从脑中提取化合物是由其他未知转运蛋白介导的。