Development of a radioprobe for quantifying the activity of multidrug resistance protein

本研究的目的是研制一种定量检测多药耐药蛋白活性的放射性探针。体内P-糖蛋白活性的测定将有助于药物的开发和剂量的优化，但该方法尚未建立。在这项研究中，我们评估了被认为是P-糖蛋白底物的化合物，以实现这一目标。然而，从大脑中提取化合物被认为是由其他未知的转运蛋白介导的。

The aim of this study is to develop a radioprobe for quantifying the activity of multidrug resistance protein. The in vivo measurement of P-glycoprotein activity would be useful for development of drugs and optimizing the dose, whereas the method has not been established. In this study, we evaluated the compound, which was considered to be a substrate for P-glycoprotein, to achieve the aim. However, the extraction of the compounds from the brain was considered to be mediated by the other unknown transporters.