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Development of regenerative therapy of central nervous system, using with asialo-erythropoietin

Development of regenerative therapy of central nervous system, using with asialo-erythropoietin
使用脱唾液酸促红细胞生成素开发中枢神经系统再生疗法
批准号:
20791020
负责人:
MIKI Yoshihito
金额:
$2.58万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2011

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中文摘要
翻译
已知全身应用大剂量重组人促红细胞生成素(RhEPO)可减轻缺血性损伤。然而,大剂量的重组人促红细胞生成素可能通过增加血液粘度而加重缺血性损害。去唾液红细胞生成素(AsialoEPO)是一种血浆半衰期极短的EPO衍生物,其促红细胞生成作用明显弱于普通EPO。我们试图确定asialo EPO在沙土鼠短暂性前脑缺血模型中是否具有与单纯EPO相同的神经保护作用,由此产生的asialo EPO与EPO一样,可以在不影响红细胞生成的情况下保护海马CA1区神经元免受缺血损伤。提示去唾液酸促红细胞生成素有可能成为未来新型的神经保护剂。
英文摘要
Systemic administration of high-dose recombinant human erythropoietin(rhEPO) is known to attenuate ischemic injury. However, high-dose rhEPO might aggravate ischemic lesions by increasing blood viscosity because of its erythropoietic effects. Asialoerythropoietin(asialoEPO), an EPO derivative with an extremely short plasma half-life, has considerably lesser erythropoietic effect than that of naive EPO. We attempted to determine whether asialoEPO exerts the same neuroprotective effect as naive EPO in a gerbil transient forebrain ischemia model, and resulting multiple dosing of asialoEPO, like EPO, could protect the hippocampal CA1 neurons from ischemic damage without affecting erythropoiesis. This data suggested that asialoEPO would be novel neuro-protective agent in the future.
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DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Yamashita T, Nonoguchi N, Ikemoto T, Miyatake S, Kuroiwa T, 山下太郎]
通讯作者: 山下太郎
Asialoerythropoietin attenuates neuronal cell death in the hippocampal CA1 region after transient forebrain ischemia in a gerbil model
亚洲促红细胞生成素可减轻沙鼠模型短暂前脑缺血后海马 CA1 区神经元细胞死亡
DOI: 10.1179/016164110x12700393823336
发表时间: 2010
期刊: Neurological Research
影响因子: 1.9
作者: [T. Yamashita, N. Nonoguchi, T. Ikemoto, S. Miyatake, T. Kuroiwa]
通讯作者: T. Kuroiwa
海外基金