Novel hybrid bone filling material of self-assembling peptide scaffold and artificial framework

自组装肽支架与人工框架的新型混合骨填充材料

• 批准号: 20791041
• 负责人: MISAWA Haruo
• 金额: $ 2.75万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791041/
• 关键词: 四肢機能再建学; 骨再生; 骨充填剤; PEEK材; SAPS; 複合素材; 骨伝導性

Bone filling materials should have enough strength for weight bearing and adequate osteoconductive property. But these properties are incompatible. In this study, we used hybrid materials of Self-assembling Peptide PuraMatrix and Polyetheretherketone Cage. PuraMatrix has good osteoconductive property and Polyetheretherketone Cage has enough strength for bone filing material. We showed that these hybrid materials were useful for repairing the bone defects in Rat's femurs.

骨填充材料应具有足够的承重强度和良好的骨传导性能。但这些属性是不相容的。本研究采用自组装肽PuraMatrix和聚醚醚酮笼的杂化材料。PuraMatrix具有良好的骨传导性能，聚醚醚酮椎间融合器具有足够的骨填充材料强度。结果表明，这些杂化材料对大鼠股骨骨缺损具有良好的修复作用。

项目成果

Bone Repair Using a Hybrid Scaffold of Self-Assembling Peptide PuraMatrix and Polyetheretherketone Cage in Rats

• DOI: 10.3727/096368910x508906
• 发表时间: 2010-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Nakahara, Hiroyuki;Misawa, Haruo;Ozaki, Toshifumi
• 通讯作者: Ozaki, Toshifumi

Bone Repair by Transplantation of hTERT-Immortalized Human Mesenchymal Stem Cells in Mice

• DOI: 10.1097/tp.0b013e3181ae5ba2
• 发表时间: 2009-08
• 期刊: Transplantation
• 影响因子: 6.2
• 作者: H. Nakahara;Haruo Misawa;Takahiro Hayashi;E. Kondo;Takeshi Yuasa;Yasuhiro Kubota;M. Seita;Hironobu Kawamoto;Wael Hassan;Reham A R A Hassan-Reham-A-R-A-Hassan-121641758;Shahid M Javed;Masato Tanaka;H. Endo;H. Noguchi;S. Matsumoto;K. Takata;Y. Tashiro;S. Nakaji;T. Ozaki;N. Kobayashi

自己重合ペプチドスキャホールドに人工骨格を併用した骨充填剤によるラット大腿骨欠損の再生

利用自聚肽支架和人工骨骼骨填充剂再生大鼠股骨骨缺损

• 发表时间: 2009
• 作者: 中原啓行、三澤治夫、林隆宏;ほか
• 通讯作者: ほか