Mechanism of the development of central pain - relationships with intracerebral adrenoceptors

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For elucidating the factors contributing to the development of central pain, relationships between the effect of local anesthetics and intracerebral adrenoceptors were examined in animals. Propranolol, a beta adrenoceptor antagonist, suppressed the effect of local anesthetics on the central nervous system at small doses which do not affect the respiratory, circulatory conditions or threshold for pain. Intracerebroventricular propranolol was approximately 100-times more potential for suppressing the effect of local anesthetics compared with that administered intravenously. These results suggest that central nervous system effect of local anesthetics was affected by intracerebral adrenoceptors and these receptors may affect pain threshold via GABAergic neurons.