Analysis of trmorigenesis and drug-resistance of ovarian/endometrial cancer due to imbalance of activin and inhibin.

在卵巢子宫内膜异位症和正常子宫内膜中未观察到α-亚基的免疫染色。卵巢子宫内膜异位症和正常子宫内膜组织中均可见激活素A、激活素受体IA、IB、IIA、IIB型、Smad 2、Smad 3和Smad 4的阳性表达，提示卵巢子宫内膜异位症和正常子宫内膜组织中可能存在激活素A，而非激活素B。激活素信号转导系统可能存在于卵巢子宫内膜异位症和正常子宫内膜中。

No immunostaining for the a-subunit of inhibin was observed in ovarian endometriosis and the normal endometrium. Positive immunostaining for the βA-subunit of inhibin, activin A, activin receptors type IA, type IB, type IIA, type IIB, Smad2, Smad3 and Smad4 was observed in ovarian endometriosis and the normal endometrium.These results suggest that activin A, but not inhibins, might be produced by ovarian endometriosis and the normal endometrium, and that the activin signal transduction system might exist in both ovarian endometriosis and the normal endometrium.