Analysis of trmorigenesis and drug-resistance of ovarian/endometrial cancer due to imbalance of activin and inhibin.

激活素和抑制素失衡引起的卵巢/子宫内膜癌的发生和耐药性分析。

• 批准号: 20791157
• 负责人: MABUCHI Yasushi
• 金额: $ 2.75万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791157/
• 关键词: アクチビン・インヒビン; 卵巣癌; アクチビン; インヒビン; 子宮内膜癌; 抗癌剤耐性

No immunostaining for the a-subunit of inhibin was observed in ovarian endometriosis and the normal endometrium. Positive immunostaining for the βA-subunit of inhibin, activin A, activin receptors type IA, type IB, type IIA, type IIB, Smad2, Smad3 and Smad4 was observed in ovarian endometriosis and the normal endometrium.These results suggest that activin A, but not inhibins, might be produced by ovarian endometriosis and the normal endometrium, and that the activin signal transduction system might exist in both ovarian endometriosis and the normal endometrium.

在卵巢子宫内膜异位症和正常子宫内膜中未观察到α-亚基的免疫染色。卵巢子宫内膜异位症和正常子宫内膜组织中均可见激活素A、激活素受体IA、IB、IIA、IIB型、Smad 2、Smad 3和Smad 4的阳性表达，提示卵巢子宫内膜异位症和正常子宫内膜组织中可能存在激活素A，而非激活素B。激活素信号转导系统可能存在于卵巢子宫内膜异位症和正常子宫内膜中。

项目成果

Immunohistochemical localization of inhibin and activin subunits,activin receptors and Smads in ovarian endomtriosis

卵巢子宫内膜异位症中抑制素和激活素亚基、激活素受体和 Smad 的免疫组织化学定位

• 发表时间: 2010
• 期刊: International Journal of Molecular Medicine 25
• 作者: Yasushi Mabuchi;Mareo Yamoto;Sawako Minami;Naohiko Umesski
• 通讯作者: Naohiko Umesski

Immunohistochemical localization of inhibin and activin subunits, activin receptors and Smads in ovarian endometriosis

• DOI: 10.3892/ijmm_00000308
• 发表时间: 2010-01-01
• 期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
• 影响因子: 5.4
• 作者: Mabuchi, Yasushi;Yamoto, Mareo;Umesaki, Naohiko
• 通讯作者: Umesaki, Naohiko