Analysis of trmorigenesis and drug-resistance of ovarian/endometrial cancer due to imbalance of activin and inhibin.
Analysis of trmorigenesis and drug-resistance of ovarian/endometrial cancer due to imbalance of activin and inhibin.
激活素和抑制素失衡引起的卵巢/子宫内膜癌的发生和耐药性分析。
批准号：
20791157
负责人：
MABUCHI Yasushi
金额：
$2.75万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2009
中文摘要
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英文摘要
No immunostaining for the a-subunit of inhibin was observed in ovarian endometriosis and the normal endometrium. Positive immunostaining for the βA-subunit of inhibin, activin A, activin receptors type IA, type IB, type IIA, type IIB, Smad2, Smad3 and Smad4 was observed in ovarian endometriosis and the normal endometrium.These results suggest that activin A, but not inhibins, might be produced by ovarian endometriosis and the normal endometrium, and that the activin signal transduction system might exist in both ovarian endometriosis and the normal endometrium.
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会议论文
Immunohistochemical localization of inhibin and activin subunits,activin receptors and Smads in ovarian endomtriosis
卵巢子宫内膜异位症中抑制素和激活素亚基、激活素受体和 Smad 的免疫组织化学定位
卵巢子宫内膜异位症中抑制素和激活素亚基、激活素受体和 Smad 的免疫组织化学定位
DOI：
--
发表时间：
2010
期刊：
International Journal of Molecular Medicine 25
影响因子：
--
作者：
[Yasushi Mabuchi, Mareo Yamoto, Sawako Minami, Naohiko Umesski]
通讯作者：
Naohiko Umesski
DOI：
10.3892/ijmm_00000308
发表时间：
2010-01-01
期刊：
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
影响因子：
5.4
作者：
[Mabuchi, Yasushi, Yamoto, Mareo, Umesaki, Naohiko]
通讯作者：
Umesaki, Naohiko
海外基金
