Polymorphism of DNA repair genes are association with head and neck carcinoma.

DNA修复基因多态性与头颈癌有关。

• 批准号: 20791197
• 负责人: HASHIMOTO Tomoko
• 金额: $ 2.08万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791197/
• 关键词: 癌; 遺伝子多型; DNA修復酵素

Peripheral blood samples from 226 cases of head and neck cancer (HNSCC) and 227 age-and-gender matching controls were collected and were analyzed by PCR-RFLP to determine the genotypic frequency of DNA repair genes(XRCC1, XRCC3, XPC, XPD, XPG). We found that the frequency of Gln/Gln at XPC Lys939Gln was significantly higher in head and neck cancer cases (p=0.028). XRCC3 Thr241Met polymorphism was associated with smoking status of HNSCC.

收集226例头颈癌患者和227例年龄、性别匹配的正常人外周血，采用聚合酶链式反应-限制性片段长度多态性方法检测DNA修复基因XRCC1、XRCC3、XPC、XPD、XPG的基因频率。我们发现在头颈癌患者中，XPC Lys939Gln的Gln/Gln频率显著升高(p=0.028)。XRCC3Thr241Met基因多态与HNSCC吸烟状态相关。