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Polymorphism of DNA repair genes are association with head and neck carcinoma.

Polymorphism of DNA repair genes are association with head and neck carcinoma.
DNA修复基因多态性与头颈癌有关。
批准号:
20791197
负责人:
HASHIMOTO Tomoko
金额:
$2.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
Peripheral blood samples from 226 cases of head and neck cancer (HNSCC) and 227 age-and-gender matching controls were collected and were analyzed by PCR-RFLP to determine the genotypic frequency of DNA repair genes(XRCC1, XRCC3, XPC, XPD, XPG). We found that the frequency of Gln/Gln at XPC Lys939Gln was significantly higher in head and neck cancer cases (p=0.028). XRCC3 Thr241Met polymorphism was associated with smoking status of HNSCC.
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海外基金