Elucidation of inner ear inflammation and basic research of therapeutic strategy for hearing impairment with a blockade of interleukin 6

对于听力损失治疗的临床应用，用MR 16 -1处理暴露于噪声的小鼠并进行评价。在用MR 16 -1处理的噪声暴露小鼠中注意到听力改善。组织学分析显示螺旋神经节神经元的减少在MR 16 -1治疗组中得到改善。与对照组相比，MR 16 - 1处理后耳蜗螺旋神经节内活化的巨噬细胞数量明显减少，对噪声损伤耳蜗具有功能和病理保护作用。IL-6阻断将是一种可行的新型听力损失治疗策略。

For clinical application of hearing loss therapy noise-exposed mice were treated with MR16-1 and evaluated. Improved hearing was noted in noise-exposed mice treated with MR16-1. Histological analysis revealed the decrease in spiral ganglion neurons was ameliorated in the MR16-1-treated group. A remarkable reduction of activated cochlear macrophages in spiral ganglions compared to the control group was observed when treated with MR16-1.Thus, MR16-1 had protective effects both functionally and pathologically for the noise-damaged cochlea. IL-6 blockade would be a feasible novel therapeutic strategy for hearing loss.