Protective effects of Channelrhodopsin-2 gene transfer on neuronal cell death

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We examined whether the transfer of ChR2 gene rescue the death of ganglion cells induced by the photoreceptor degeneration. We could clearly record the visually evoked potentials in both age of the ChR2 transferred-RCS rats though the amplitudes. These data showed that the function of retinal ganglion cells was kept after the photoreceptor degeneration.In the ChR2-expressing retina, the immunoreactivity (IM) of the p65-IM was observed in the retinal ganglion cell layer. It is known that the expression of p65 has a critical role in keeping the neuronal cell activities. These results indicated that the transfer of ChR2 gene could give some protective effect on the cell death of retinal ganglion cells following the photoreceptor degeneration.