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Effects of WT1 gene knockdown in Wilms tumor

Effects of WT1 gene knockdown in Wilms tumor
WT1基因敲低对肾母细胞瘤的影响
批准号:
20791299
负责人:
TAKAMA Yuichi
金额:
$2.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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项目成果

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中文摘要
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英文摘要
Immunohistochemical staining revealed that in neuroblastoma (NB), differentiating cells showed strong cytoplasmic staining. Expression of WT1 was higher in mature ganglionic cells, and in the immunohistochemical analysis, the WT1 positivity for ganglioneuromas was significantly higher than that for neuroblastomas. Knockdown of WT1 gene promoted the proliferation of NB69 cells (P<.01).The WT1 may govern cell differentiation and suppress cell proliferation in NB. The WT1 does not act as an oncogene, but it may participate in the maturation of NB, therefore can be a potential therapeutic target for cell differentiation.
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