Inhibition of bone resorption by RNA aptamer for immunoregulatory receptor PD-1 induced on activated T cell.

PD-1是免疫反应的负调节剂。我们假设PD-1参与炎症性骨吸收，PD-1信号有可能作为抑制炎症性骨吸收的药物靶点。PD-1的RNA适体可能是候选者，因此我们尝试制备适体。在研究期间，制备适体并研究其效果在技术上是困难的。为了获得更有效和安全的药物产品的基础知识，重要的是在未来创造新的药物发现技术，如适配体。

PD-1 is a negative regulator of immune responses. We made a hypothesis that PD-1 is involved in inflammatory bone resorption and that PD-1 signal has possibilities as a drug target which inhibit inflammatory bone resorption. RNA aptamer for PD-1 might be a candidate and thus we tried to make an aptamer. During the research period, it was technically difficult to make the aptamer and to investigate the effect. To get basic knowledge of more effective and safety medical product, it is important to create new drug-discovery technology like an aptamer in the future.