Investigation of disease-associated proteome maps in oral lesion

在这项研究中，我们使用蛋白质组学的方法来确定口腔病变中与疾病相关的蛋白质组图谱。利用这一策略，我们在恶性纤维组织细胞瘤(MFH)中检测到四种上调的蛋白质和四种下调的蛋白质。我们采用了我们之前的微阵列数据，包括口腔鳞状细胞癌和腺样囊性癌，以比较MFH中的蛋白表达模式。然后，我们通过比较基因芯片数据中的mRNA表达模式和蛋白质组学数据中的蛋白质表达模式，选择了三种蛋白质，Transglin 2，磷酸甘油酸激酶1和Vimentin。因此，我们的数据表明，这三种蛋白可能不仅是口腔MFH的潜在分子标志物，而且可能是口腔恶性肿瘤的潜在分子标志物。

In this study, we performed proteomics approach to identify the disease-associated proteome maps in oral lesion. Using this strategy, we detected four up-regulated proteins and four down-regulated proteins in malignant fibrous histiocytoma (MFH). We adopted our previous microarray data, including oral squamous cell carcinoma and adenoid cystic carcinoma, to compare with patterns of protein expressions in MFH. Then, we selected the three proteins, Transgelin 2, phosphoglycerate kinase 1 and Vimentin, by comparing patterns of mRNA expressions in microarray data with patterns of protein expressions in proteomics data. Therefore, our data indicate that three proteins may be a potential novel molecular marker of not only oral MFH but also oral malignant tumors.