Idenfication and function of specific protein induced by candida albicans from human oral mucosal cell

口腔粘膜细胞被认为影响宿主对白色念珠菌的炎症反应。在永生化的口腔角质形成细胞(RT7)中加入钙活体细胞后，多种趋化因子的mRNA水平增加，而CX3CL1的水平不变。相反，活体钙和热灭活钙可增加人永生化口腔成纤维细胞(GT1)中CX3CL1的mRNA和蛋白表达。GT1细胞中CX3CL1mRNA的表达也被非白念珠菌刺激增强。此外，CX3CL1趋化素结构域对白色念珠菌具有抗真菌活性。口腔成纤维细胞分泌的CX3CL1在口腔对白色念珠菌感染的免疫应答中起重要作用。

Oral mucosal cells are thought to influence host inflammatory responses against Candida albicans(Ca). Addition of Ca live cells to human immortalized oral keratinocytes (RT7) resulted in increases in mRNA levels of multiple chemokines, however not of CX3CL1. In contrast, live and heat-killed Ca caused an increase in CX3CL1 mRNA and protein expression in human immortalized oral fibroblasts (GT1). CX3CL1 mRNA expression in GT1 cells was also enhanced by stimulation with a non-albicans species of Candida. Further, the CX3CL1 chemokine domain showed antifungal activity against C. albicans. CX3CL1 secreted by oral fibroblasts appears to play an important role in oral immune response to C. albicans infection.