Study on the mechanism of malignant transformation of oral leukoplakia mediated by p63 and Notch signaling pathway

p63和Notch信号通路介导的口腔白斑恶变机制研究

• 批准号: 20791531
• 负责人: KAWANO Shintaro
• 金额: $ 2.66万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791531/
• 关键词: 口腔扁平上皮癌; 癌化; 白板症; p63; Notchシグナル; 分化; 上皮間葉転換; 上皮異形成; 癌幹細胞; 口腔白板症

This study was addressed to reveal the molecular mechanisms of malignant transformation of oral leukoplakia (OL) into squamous cell carcinoma (OSCC). In the OL, LI of p63 increased significantly according to the severity of epithelial dysplasia, though that of Notch1 decreased. p63-LI in the OL with malignant transformation was significantly higher than that in the OL without. In the OSCC, these LIs increased significantly in association with the histologic grade. Increased ΔNp63 expression was possibly involved in malignant transformation in epithelial dysplasia and proliferation and differentiation of OSCC.

本研究旨在揭示口腔白斑(OL)向鳞状细胞癌(OSCC)恶变的分子机制。在OL中，P63的LI随上皮异型增生程度的加重而显著增加，而Notch1的LI随上皮异型增生程度的加重而降低。癌变组P63-LI显著高于未癌变组。在口腔鳞癌中，这些LI随着组织学分级的增加而显著增加。ΔNp63表达增强可能参与了口腔鳞癌上皮异型增生恶变和增殖分化的过程。

项目成果

Prediction and monitoring of the response to chemoradiotherapy in oral squamous cell carcinomas using a pharmacokinetic analysis based on the dynamic contrast-enhanced MR imaging findings European Radiology

使用基于动态对比增强 MR 成像结果的药代动力学分析来预测和监测口腔鳞状细胞癌对放化疗的反应欧洲放射学

• 期刊: in press
• 作者: Toru Chikui;Shintaro Kawano;Toshiyuki Kawazu;Masamitsu Hatakenaka;Syouzou Koga;Masahiro Ohga,Yoshio Matsuo;Syunya Sunami;Tsuyoshi Sugiura;Yoshiyuki Shioyama;Makoto Obara;Kazunori Yoshiura
• 通讯作者: Kazunori Yoshiura

Immunohistochemical analysis of cytokeratin 17 in oral squamous cell carcinoma

口腔鳞状细胞癌中细胞角蛋白17的免疫组织化学分析

• 发表时间: 2010
• 作者: R KITAMURA;T TOYOSHIMA;S KAWANO;T KIYOSUE;R MATSUBARA;Y GOTO;K OOBU;S NAKAMURA
• 通讯作者: S NAKAMURA

著明な嚢胞形成を伴った顎下腺多形腺腫の1例

颌下腺多形性腺瘤伴明显囊肿形成一例

• 发表时间: 2011
• 期刊: 日本口腔腫瘍学会誌 23
• 作者: 後藤雄一;川野真太郎;大部一成;鈴木華子;松原良太;清末崇裕;小林家吉;白土雄司;中村誠司
• 通讯作者: 中村誠司

Evaluating the effect of preoperative chemoradiotherapy using a pharmacokinetic analysis of dynamic contrast enhanced MR imaging ( 1 )

使用动态对比增强MR成像的药代动力学分析评估术前放化疗的效果( 1 )

• 发表时间: 2010
• 作者: Toru Chikui;Shintaro Kawano;Yoshio Matsuo;Syunya Sunami;Takeshi Kamitani;Syozou Koga;Kazunori Yoshiura
• 通讯作者: Kazunori Yoshiura

Results of Surgical Treatment for Stages I and II Tongue Squamous Cell Carcinomas

I 期和 II 期舌鳞状细胞癌的手术治疗结果

• 发表时间: 2008
• 作者: S. Kawano;et.al.
• 通讯作者: et.al.