The fundamental study of correlation between expression of VEGF and lymphmetastasis of oral squamous cell carcinoma

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The human oral squamous cell carcinoma cell lines, HSC-2 and HSC-4 cultured under normaxia (20%O_2, 5%CO_2) and hypoxia (5%O_2, 5%CO_2, 37%). The expression of VEGF was assesed by immunohistocheical staining and RT-PCR. In imumunohisotcehiminal staining, the expression of VEGF-C was stronger under hypoxia rather than normaxia of each cell line. In RT-PCR, the expression of VEGF-C and MMP-9 were increase under hypoxia. Therefore this result suggests VEGF-C induced by hypoxia may increase ability of metasatsis in oral squamous cell carcinoma.