Significance as a therapeutic target and elucidation of EMT in a low oxygen environment of oral squamous cell carcinoma

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We compared invasion and motility and expression of E-cadherin in oral cancer cell linescultured in a normal environment and low oxygen environment. They were increased in a low oxygen environment, but suppressed by the addition of Notch inhibitors. We examined the expression of Notch-related factors in the real time PCR, showed an enhanced expression of Notch signaling in a low-oxygen environment. These results suggested possibility that induce EMT in oral cancer cell lines via the Notch pathway by low oxygen environments, and might suggest Notch passway to be a therapeutic target for inhibiting metastasis of oral cancer.