Elucidation of an aging mechanism and an anti-aging treatment in periodontal tissue

阐明牙周组织的衰老机制和抗衰老治疗

• 批准号: 20791578
• 负责人: TANAKA Nobuaki
• 金额: $ 2.75万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791578/
• 关键词: 歯肉線維芽細胞; 宿主年齢; ヒアルロン酸; b-FGF; 感受性

We studied the effect of bFGF and different HA molecular size in GF isolated from the different host ages. The bFGF showed different action by cell density. The ability of proliferation and matrix-forming were enhanced in proliferative phase during the wound healing process, and the induction of apoptosis was also enhanced in remodeling phase. These effects were more marked in younger host.

我们研究了bFGF和不同分子大小的HA对不同年龄宿主的GF的影响。bFGF的作用因细胞密度不同而不同。在创面愈合过程中，增殖期细胞增殖和基质形成能力增强，重塑期细胞凋亡诱导能力增强。这些影响在年轻宿主中更为显著。

项目成果

Inhibition of the proliferation of human periodontal ligament fibroblasts by hyaluronidase

透明质酸酶抑制人牙周膜成纤维细胞增殖

• 发表时间: 2008
• 期刊: Arch Oral Biol. 53
• 作者: Amano A;Murakami J;Akiyama S. Morisaki I;Tanimoto K
• 通讯作者: Tanimoto K

Effects of mechanical stimuli on the synthesis of superficial zone protein in chondrocytes

• DOI: 10.1002/jbm.a.32295
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Kamiya, T.;Tanimoto, K.;Tanne, K.
• 通讯作者: Tanne, K.

Effects of mechanical load on the expression and activity of hyaluronidase in cultured synovial membrane cells.

机械负荷对培养滑膜细胞中透明质酸酶表达和活性的影响。

• 发表时间: 2009
• 期刊: J Biomed Mater Res A. (In press)
• 作者: Jorge Zeredo;Tatsunori Shibazaki;Kyoko Sanefuji;Masako Yoshimatsu;Joseph Yozgatian;Sia Sheau Soon;Hitoshi Hotokezaka;Hideki Kitaura;黒瀬 雅之;Kitamura R.
• 通讯作者: Kitamura R.

Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a co-culture system

• DOI: 10.1111/j.1600-0722.2010.00710.x
• 发表时间: 2010-04-01
• 期刊: EUROPEAN JOURNAL OF ORAL SCIENCES
• 影响因子: 1.9
• 作者: Lin, Yu-Yu;Tanaka, Nobuaki;Tanne, Kazuo
• 通讯作者: Tanne, Kazuo

The Effect of Mechanical Loading on the Metabolism of Growth Plate Chondrocytes

• DOI: 10.1007/s10439-008-9462-7
• 发表时间: 2008-02
• 期刊: Annals of Biomedical Engineering
• 影响因子: 3.8
• 作者: M. Ueki;N. Tanaka;K. Tanimoto;C. Nishio;Kobun Honda;Yu-Yu Lin-Yu;Y. Tanne;Satoru Ohkuma;T. Kamiya;E. Tanaka;K. Tanne