Analysis of absorbing factors against tooth roots induced by mechanical stress from periodontal tissues
Analysis of absorbing factors against tooth roots induced by mechanical stress from periodontal tissues
批准号:
20791587
负责人:
OKAYAMA Miki
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
采用重力载荷(G-loading)对人牙周韧带(PDL)进行机械应力模拟。在7G时G-loading, ERK在5 min后磷酸化,在5 min时用ATP处理细胞观察ERK的磷酸化。g负荷对PDL的ATP也有诱导作用。P2Y特异性激动剂通过g负载和UTP减少ERK磷酸化,从而诱导ERK磷酸化。因此,g负载通过ATP和P2Y受体诱导ERK磷酸化。
英文摘要
Gravity loading (G-loading) was applied to human periodontal ligament (PDL) as a model of mechanical stress. ERK was phosphorylated after 5 min by G-loading at 7G and the phosphorylation of ERK was observed with ATP treatment to the cells at 5 min. G-loading also induced ATP in PDL. An inhibitor of purenargic receptor diminished ERK phosphorylation by G-loading and UTP, P2Y specific agonist induced ERK phosphoryaltion. Thus, G-loading induced ERK phophrylation via ATP and P2Y receptor.
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DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[設楽彰子, 岡山三紀, 荒川俊哉, 溝口到, 田隈泰信]
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田隈泰信
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DOI:
--
发表时间:
2008
期刊:
影响因子:
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作者:
[岡山三紀, 六車武史, 村田勝, 柴田考典, 溝口到]
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溝口到
DOI:
10.1247/csf.09013
发表时间:
2009-01-01
期刊:
CELL STRUCTURE AND FUNCTION
影响因子:
1.5
作者:
[Okayama, Miki, Arakawa, Toshiya, Takuma, Taishin]
通讯作者:
Takuma, Taishin
重力負荷による歯根膜細胞のシグナル応答機構
牙周膜细胞对重力负荷的信号反应机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[伊藤麻衣, 岡山三紀, 荒川俊哉, 田隈泰信, 溝口到]
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Clinical Statistics of 43 Cases using Midpalatal Implants and Application of Collagenous Sponge for Bone Defect after Removal of Implants
腭中种植体及胶原海绵应用修复种植体取出后骨缺损43例临床统计
DOI:
--
发表时间:
2009
期刊:
Journal of Hard Tissue Biology 18(4)
影响因子:
--
作者:
[MURATA Masaru, OKAYAMA Miki, HINO Jun, ITO Katsutoshi, MIZOGUCHI Itaru, ARISUE Makoto]
通讯作者:
ARISUE Makoto
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Development of patient education program to nurture the "ability to connect with family members" in dialysis patients with diabetes
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批准号:17K17453
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.08万
-
财政年份:2017
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负责人:OKAYAMA Miki
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依托单位:
DNA chip analysis and identification of the genes induced in human periodontalligament to cause tooth root resorption.
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批准号:22792065
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
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财政年份:2010
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负责人:OKAYAMA Miki
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依托单位:
海外基金