DNA chip analysis and identification of the genes induced in human periodontalligament to cause tooth root resorption.

人PDL细胞在7G负荷作用2小时后，ID1(DNA结合抑制物1)、Egr1(早期生长反应1)、SGK1(G蛋白信号转导调节因子2)和DUSP1(双特异性磷酸酶1)表达上调。MEK抑制剂U0126可抑制这些基因的上调和磷酸化。因此，ERK的磷酸化在机械应力诱导的基因中起着至关重要的作用。机械应力通过细胞外基质的降解控制牙周组织的改建和牙根的吸收。

ID1 (Inhibitor of DNA binding 1), EGR1 (Early growth response 1), SGK1 (Regulator of G-protein signaling 2) and DUSP1 (Dual specificity phosphatase 1) were upregulated in 2 hours by 7G-loading in human PDL cells. U0126, MEK inhibitor diminished up-regulation and phosphorylation of these genes. Thus, the phosphorylation of ERK had crucial rule in genes induced by mechanical stress. It was also suggested that the mechanical stress controlled remodeling of periodontal tissues and tooth root resorption through extracellular matrix degradation.