The possibility of osteoproteger in as a topical application drug inperiodontal therapy.

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The purpose of this study was to investigate the effects of osteoprotegerin (OPG), decoy reseptor of RANKL, on alveolar bone resorption in rat experimental periodontitis. Morphological analysis revealed that alveolar bone resorption was significantly inhibited by OPG treatment through a decrease of osteoclast number. The expression of IL-1β fiwas similar between OPG-treated and non-treated groups. The numbers of polymorphonuclear leukocyte and blood vessel in the subepithelial connective tissue were not affected by OPG treatment. These results show that OPG may be useful as a topical application drug in periodontal therapy.