An investigation of predictive marker of bisphosphonate-related osteonecrosis of the jaw.

双膦酸盐相关颌骨坏死预测标记物的研究。

• 批准号: 22792090
• 负责人: MIHARA Chie
• 金额: $ 2.58万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22792090/
• 关键词: 歯学; ビスホスホネート; 顎骨壊死

Osteonecrosis of the jaw(BRONJ) is well-reported side effect of bisphosphonate(BPs) use. Many researchers are trying to clarify the process of BRONJ appearance and to find a predictive marker of BRONJ. But they are not known exactly. The purpose of this investigation is to find a marker to predict BRONJ appearance by morphological analysis and biochemical analysis at process of BRONJ formation. We could not find a predictive marker of BRONJ.

颌骨坏死(BRONJ)是使用双磷酸盐(BPS)的常见副作用。许多研究人员试图阐明BRONJ的出现过程，并寻找BRONJ的预测标志物。但他们并不是很清楚。本研究的目的是通过形态分析和生化分析，寻找一种预测BRONJ形成过程中BRONJ形态的标记。我们找不到BRONJ的预测指标。

项目成果

Topical and intermittent application of parathyroid hormone recovers alveolar bone loss in rat experimental periodontitis

• DOI: 10.1111/j.1600-0765.2011.01386.x
• 发表时间: 2011-12-01
• 期刊: JOURNAL OF PERIODONTAL RESEARCH
• 影响因子: 3.5
• 作者: Tokunaga, K.;Seto, H.;Nagata, T.
• 通讯作者: Nagata, T.