Molecular biological analysis of periodontitis and metabolic syndrome based on renin-angiotenshin system

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The aim of the present study was to investigate the expression of renin-angiotensin system (RAS) components, which has been considered to be concerned with several steps of metabolic syndrome, in human gingival tissues and the effects of RAS on inflammatory reactions in cultured human gingival fibroblasts (HGF). This study demonstrated that tissue RAS exists in HGT and IL-6 induced by IL-1β may be partially regulated through AT1R in HGF. These facts suggest that RAS may be involved in the regulation of inflammatory responses in periodontal disease.