Development of Maternal and Neonatal Health Care Systems for the Prevention of Neonatal Early-Onset Group B Streptococcal Disease from the Viewpoint of Medical Cooperation

点击翻译按钮获取中文摘要

[Study 1] I compared microbiological screening methods during pregnancy between mothers (group A) whose neonates developed early onset group B streptococcal disease (EOGBSD) and mothers with GBS colonization (group B) whose neonates did not. There were a significantly higher proportion of pregnant women screened before 35 gestational weeks in group A than in group B. Among EOGBSD neonates who required neonatal transport, the interval between disease onset and admission was significantly longer in neonates whose onset occurred at midnight than those at period with onset other than midnight. [Study 2] Next, I examined microbiological characteristics of invasive isolates from EOGBSD the neonates (n=14) and colonized isolates from the neonatal pharynx (n=61) and from the genital tract of pregnant women (n=247). There were no significant differences in the susceptibility of antimicrobial agents between invasive and colonized isolates. In conclusion, implementation of universal obstetric screening and development of neonatal transport systems may improve the prognosis of EOGBSD.