Development of a Novel Method for Evaluating Cardiopulmonary Functions Using Hyperpolarized Xenon-129 Magnetic Resonance

为了发展超极化氙-129磁共振无创性评价心肺功能的方法，对自主呼吸小鼠进行了多种方法和分析。因此，这些方法使得区域性地评价肺功能成为可能。在此基础上，成功地导出了全肺的肺结构和心功能参数。从应用到使用肺气肿小鼠模型的病理学评估，发现这些参数是检测肺气肿的有效生物标志物。

To develop the noninvasive method for evaluating cardiopulmonary functions using hyperpolarized xenon-129 magnetic resonance, several methods and analyses were applied to spontaneous breathing mice. As a result, these methods made possible to evaluate pulmonary functions regionally. Furthermore, the parameters related to pulmonary structure and cardiac function were successfully derived in the whole lung. From the application to pathological evaluation using a mouse model of emphysema, it was found that these parameters are the effective biomarker to detect emphysema.