Study of molecular mechanism in muscle atrophy and fiber type change by using bioimaging.
Study of molecular mechanism in muscle atrophy and fiber type change by using bioimaging.
批准号:
20800079
负责人:
MORI Shuuichi
金额:
$2.11万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (Start-up)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
Not only atrophy of muscle fibers but also fiber type transition from fast-type to slow-type has been observed as age-related changes of skeletal muscle, however, these mechanism remain to be elucidated. In this study, generation of genetically modified mice, which could definitely distinguish between fast-type fiber and slow-type fiber by expressions of fluorescence proteins, was performed. In future, it will enable novel findings about muscular atrophy-related phenomena and biomarkers by investigating the mechanism of age-related change in fiber type using these mice.
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MuSKIは神経筋シナプスの維持に重要である~研究モデル動物の確立~
MuSKI对于维持神经肌肉突触很重要 - 研究模型动物的建立 -
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, Asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y., Aoki K, Tokuyama K, Mori S., 森秀一, 森秀一, 森秀一, Mori S., 森秀一, 森秀一, 森秀一]
通讯作者:
森秀一
Activation of complement is indispensable for myasthenia gravis caused by MuSK antibodies
MuSK抗体引起的重症肌无力离不开补体的激活
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Mori S, Kubo S, Akiyoshi T, Yamada S, Miyazaki T, Shigemoto K.]
通讯作者:
Shigemoto K.
Myasthenia gravis disease mechanism and immune intervention
重症肌无力发病机制及免疫干预
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shigemoto K, Kubo S, Mori S, Yamada S, Miyazaki T, Akiyoshi T, Maruyama S.]
通讯作者:
Maruyama S.
Hepatic insulin sensitivity assessed by integrated model of hepatic and peripheral glucose regulation.
通过肝脏和外周葡萄糖调节的综合模型评估肝脏胰岛素敏感性。
DOI:
--
发表时间:
2009
期刊:
Diabetes Technol Ther 11
影响因子:
--
作者:
[Tokuyama K, Nagasaka S, Mori S, Takahashi N, Kusaka I, Kiyonaga A, Tanaka H, Shindo M, Ishibashi S.]
通讯作者:
Ishibashi S.
Hepatic insulin sensitivity assessed by integrated model of hepatic and peripheral glucose regulation
通过肝脏和外周葡萄糖调节综合模型评估肝脏胰岛素敏感性
DOI:
--
发表时间:
2009
期刊:
Diabetes Technol Ther 11
影响因子:
--
作者:
[Aoki K, Matsui J, Kubota N, Nakajima H, Iwamoto K, Takamoto I, Tsuji Y, Ohno A, Mori S, Tokuyama K, Murakami K, Asano T, Aizawa S, Tobe K, Kadowaki T, Terauchi Y., Aoki K, Tokuyama K]
通讯作者:
Tokuyama K
共 9 条
Examination of treatment of myasthenia gravis with antibodies against muscle-specific kinase using experimental animal model.
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批准号:23791009
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2011
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负责人:MORI Shuuichi
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依托单位:
海外基金