Examination of treatment of myasthenia gravis with antibodies against muscle-specific kinase using experimental animal model.
Examination of treatment of myasthenia gravis with antibodies against muscle-specific kinase using experimental animal model.
批准号:
23791009
负责人:
MORI Shuuichi
金额:
$2.66万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
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英文摘要
This study examined the availability of a novel drug in the treatment of myasthenia gravis with antibodies against muscle-specific kinase (MuSK-MG) using experimental animal model. The results provided the evidence that only low-dose cholinesterase inhibitors should be used to avoid side effect, and that 3,4-diaminopyridine will be effective as a mainstay in the symptomatic therapy of MuSK-MG.
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Establishment and characterization of hepatocytes from an Immortomouse/SMP30/GNL knockout mouse hybrid lacking vitamin C to study vitamin C transport
缺乏维生素 C 的 Immortomouse/SMP30/GNL 敲除小鼠杂交肝细胞的建立和表征,用于研究维生素 C 转运
DOI:
10.1093/jb/mvr109
发表时间:
2011
期刊:
Journal of biochemistry
影响因子:
2.7
作者:
[Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A.]
通讯作者:
A.
神経筋接合部の異常と筋萎縮
神经肌肉接头异常和肌肉萎缩
DOI:
--
发表时间:
2010
期刊:
メジカルビュー社老年医学
影响因子:
--
作者:
[大田潔江,大田光煕,重本和宏, (他一名), 昼間深・馬渡和真・北森武彦, 富田浩史, 重本和宏,森秀一,久保幸穂,山田茂,秋好沢諭,宮崎剛]
通讯作者:
重本和宏,森秀一,久保幸穂,山田茂,秋好沢諭,宮崎剛
神経筋接合部の維持機構と筋萎縮.
神经肌肉接头和肌肉萎缩的维持机制。
DOI:
--
发表时间:
2013
期刊:
医学のあゆみ.
影响因子:
--
作者:
[森 秀一, 重本 和宏.]
通讯作者:
重本 和宏.
Distinct mechanisms between divalent and monovalent MuSK antibodies involved with dysfunction of MuSK leading to myasthenia gravis
二价和单价 MuSK 抗体与 MuSK 功能障碍导致重症肌无力的不同机制
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Mori S, Kubo S, Yamada S, Miyazaki T, Shigemoto K]
通讯作者:
Shigemoto K
Distinct mechanism between divalent and monovalent MuSK antibodies are involved with dysfunction of MuSK leading to myasthenia gravis.
二价和单价 MuSK 抗体之间的独特机制与导致重症肌无力的 MuSK 功能障碍有关。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Amano, A., Handa, S., Aigaki, T., Shigemoto, K., Maruyama, N., Ishigami, A., Mori S., 森 秀一, 森 秀一., Mori S.]
通讯作者:
Mori S.
共 19 条
Study of molecular mechanism in muscle atrophy and fiber type change by using bioimaging.
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批准号:20800079
-
项目类别:Grant-in-Aid for Young Scientists (Start-up)
-
资助金额:$2.11万
-
财政年份:2008
-
负责人:MORI Shuuichi
-
依托单位:
海外基金