Elucidation of the molecular recognition mechanism to venomous proteins of a novel small serum protein (SSP) from venomous snake serum.

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Snake venom contains many proteins with several pharmacological functions. On the other hand, endogenous inhibitors to these venomous proteins are present in the snake serum. In the present study, some serum proteins were purified from serum of Habu snake, and the inhibitory effects to the neurotoxin and the hemorrhagic toxin from the own venom were examined. Moreover, one of these proteins strongly inhibited the protein that induces the death of vascular cells. This study also clarified how the serum proteins recognize the venom proteins.