Molecular recognition mechanism of the small serum proteins(SSPs) events at venomous snake serum against venomous proteins.

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Snake venom contains many proteins with several pharmacological functions. On the other hand, endogenous inhibitors of these venomous proteins are present in the snake serum. However, the molecular mechanisms of recognition and inactivation of these inhibitors are unknown. This study has clarified how they specifically inhibit a neurotoxin and an apoptosis-inducing toxin from T. flavoviridis(Habu). In addition, the residues involved in the interactions between the antivenom-proteins and venomous proteins were investigated by mutantational and three-dimensional alalysis.