Effects of flavonoids on TLR-mediated inflammatory changes in adipocytes

肥胖的脂肪组织产生过量的炎症因子，包括游离脂肪酸(FFA)和脂肪因子，它们参与了代谢综合征的发展。因此，了解脂肪细胞炎症的调控机制对改善代谢综合征具有重要意义。在这篇报道中，我们发现柑橘类黄酮通过调节脂肪细胞内信号，影响脂肪细胞FFA的分泌、脂肪因子的表达、TLR的表达和TLR信号转导。

Obese adipose tissue produces excess inflammatory factors, including free fatty acid (FFA) and adipokines, which are involved in the development of metabolic syndrome. Thus, understanding the regulatory mechanism of adipocytes inflammation is important in the improvement of metabolic syndrome. In this report, we show that citrus flavonoids affect the FFA secretion, adipokines expression, TLR expression and TLR signaling through the regulation of intracellular signaling in adipocytes.