Analysis of nano-drug delivery system in tumor with low vascular permeability with permeability-enhancing agents.

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We clarified appropriate sizes of nanoparticles to use enhanced permeability and retention effects by the single molecular imaging method in vivo. The dynamics of the particles depends on the place in the tumor. We made vascular endothelial growth factor (VEGF)-quantum dot (Qdot) complex. VEGF-Qdot complex attaches vascular endothelial growth factor receptor (VEGFR) expressing tumor cell in vitro higher than platlet-derived growth factor (PDGF)-Qdot and Qdot only. We confirmed reduced blood flow of the mouse ischemic limb model we made by the laser Doppler apparatus.