Biological role of asymmetric distribution of fatty acids in membrane phospholipids

我们研究了可能参与甘油磷脂脂肪酸组成的磷脂重塑酶。我们的研究揭示了一些酶在小鼠大脑神经元中具有特定的表达模式。我们建立了一种通过小鼠海马原代神经元培养来调控神经元磷脂脂肪酸组成的方法。我们的研究结果表明，具有不同脂肪酸组成的细胞可能具有不同的神经元功能。我们目前正在研究通过调节脂肪酸组成参与这种功能变化的酶。

We have studied phospholipid-remodeling enzymes that are possibly involved in fatty acid composition in glycerophospholipid. Our study has revealed that some of the enzymes have specific expression pattern in neuron in mice brain. We have established a method that manipulates fatty acid composition in phospholipid in neuron by using mouse primary hippocampal neuronal culture. Our results suggest the possibility that neuronal function may differ between cells that have different fatty acid composition. We are currently investigating the enzymes that are involved in this functional change by modulation of fatty acid composition.