Biological role of asymmetric distribution of fatty acids in membrane phospholipids

膜磷脂中脂肪酸不对称分布的生物学作用

• 批准号: 20890047
• 负责人: TOKUOKA Suzumi
• 金额: $ 1.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890047/
• 关键词: リン脂質; アシル転移酵素; 神経細胞; 脂質; 酵素; 細胞膜; 脂肪酸非対称性

We have studied phospholipid-remodeling enzymes that are possibly involved in fatty acid composition in glycerophospholipid. Our study has revealed that some of the enzymes have specific expression pattern in neuron in mice brain. We have established a method that manipulates fatty acid composition in phospholipid in neuron by using mouse primary hippocampal neuronal culture. Our results suggest the possibility that neuronal function may differ between cells that have different fatty acid composition. We are currently investigating the enzymes that are involved in this functional change by modulation of fatty acid composition.

我们研究了可能参与甘油磷脂中脂肪酸组成的磷脂重塑酶。我们的研究揭示了某些酶在小鼠脑神经元中具有特异的表达模式。我们建立了一种利用原代培养的小鼠海马神经元来调控神经元磷脂中脂肪酸组成的方法。我们的研究结果表明，神经元功能可能不同的细胞之间，具有不同的脂肪酸组成的可能性。我们目前正在研究参与这种功能变化的脂肪酸组成的调制酶。