Truncation of parathyroid hormone in parathyroid cells

甲状旁腺细胞中甲状旁腺激素的截短

• 批准号: 20590980
• 负责人: INABA Masaaki
• 金额: $ 2.75万
• 依托单位: Osaka City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590980/
• 关键词: 人工透析学; 副甲状腺アデノーマ; 2次性副甲状腺機能亢進症; 副甲状腺ホルモン; カルシウム感知受容体; N端断片化PT H; N端断片化PTH; 副甲状腺機能亢進症

Extracellular calcium concentration regulates parathyroid hormone (PTH) secretion via calcium-sensing receptor (CaR) on the parathyroid cell surface. N-terminal truncation of PTH is also regulated by extracellular calcium concentration. The N-terminal truncation is thought to be one of the regulatory mechanisms to secrete 1-84PTH from parathyroid cells, however, signal pathways of the mechanism in the cells are not yet reported. We attempt to determine whether the pathways of N-terminal truncation are identical from those of (1-84)PTH secretion in primary cultured human parathyroid cells. It is suggested that the N-terminal truncation of PTH regulated by extracellular calcium concentration has at least partly independent intracellular signaling systems from the (1-84)PTH secretion in human parathyroid cells.

细胞外钙浓度通过甲状旁腺细胞表面的钙敏感受体（CaR）调节甲状旁腺激素（PTH）的分泌。PTH的N-末端截短也受细胞外钙浓度的调节。N端截短被认为是甲状旁腺细胞分泌1- 84 PTH的调节机制之一，但该机制在细胞中的信号通路尚未见报道。我们试图确定在原代培养的人甲状旁腺细胞中，N-末端截短的途径是否与（1-84）PTH分泌的途径相同。这表明，在人甲状旁腺细胞中，由细胞外钙离子浓度调节的PTH N-末端截短至少部分地独立于（1-84）PTH分泌的细胞内信号系统。

项目成果

The Levels of Somatostatin Receptors in Causative Tumors of Oncogenic Osteomalacia Are Insufficient for Their Agonist to Normalize Serum Phosphate Levels

• DOI: 10.1007/s00223-010-9369-9
• 发表时间: 2010-06-01
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Ishii, Akira;Imanishi, Yasuo;Nishizawa, Yoshiki
• 通讯作者: Nishizawa, Yoshiki

Glycated albumin as an improved indicator of glycemic control in hemodialysis patients with type 2 diabetes based on fasting plasma glucose and oral glucose tolerance test

• DOI: 10.1016/j.biopha.2008.04.002
• 发表时间: 2009-03-01
• 期刊: BIOMEDICINE & PHARMACOTHERAPY
• 影响因子: 7.5
• 作者: Nagayama, Harumi;Inaba, Masaaki;Nishizawa, Yoshiki
• 通讯作者: Nishizawa, Yoshiki

Association of serum TRAIL levels with atherosclerosis in patients with type 2 diabetes mellitus

• DOI: 10.1016/j.diabres.2010.11.034
• 发表时间: 2011-03-01
• 期刊: DIABETES RESEARCH AND CLINICAL PRACTICE
• 影响因子: 5.1
• 作者: Kawano, Naoya;Mori, Katsuhito;Inaba, Masaaki
• 通讯作者: Inaba, Masaaki

Clinical and Biochemical Response of TNFRSF11A-Mediated Early-Onset Familial Paget Disease to Bisphosphonate Therapy

TNFRSF11A 介导的早发家族性佩吉特病对双膦酸盐治疗的临床和生化反应

• 发表时间: 2008
• 期刊: Calcif Tissue Int 83
• 作者: Riches PL;Imanishi Y;他2名
• 通讯作者: 他2名

The administration of an active vitamin D3 analogue reduced the serum concentrations of 1-84 and truncated parathyroid hormone in pseudohypoparathyroidism type Ib patients

服用活性维生素 D3 类似物可降低 Ib 型假性甲状旁腺功能减退症患者的血清 1-84 和截短甲状旁腺激素浓度

• 发表时间: 2010
• 期刊: Endocr J 57
• 作者: Ishii A 総8名;Imanishi Y (2番目);Inaba M (7番目)
• 通讯作者: Inaba M (7番目)