Exploration of intracellular protease property and control factors of neurosin with α-synuclein degrading activity

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We investigated proteolytic activity and control factors of human neurosin using cultured cells. Heterologous expression of pre-pro-neurosin was localizedto the endoplasmic reticulum and secreted. Extracellular neurosin had protease activity and can degrade α-synuclein. Meanwhile, intracellular neurosin did not have α-synuclein -degrading activity. These findings suggest that neurosin is involved in degradation ofα-synuclein as an extracellular protease.