Targeting the TGF-beta type I receptor kinase as a molecular therapy for muscular dystrophy
Targeting the TGF-beta type I receptor kinase as a molecular therapy for muscular dystrophy
批准号:
20591013
负责人:
OHSAWA Yutaka
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Inhibitor targeting the TGF-β type I receptor kinase, recently developed for cancer, reverses impaired myoblast differentiation caused by myostatin, activin, and TGF-β1. Inhibitor ameliorated muscular atrophy in a caveolin-3-deficient muscular dystrophy model with decrease of p21, a target gene of the TGF-β, and with increase of satellite cells. Inhibitor thus could be a rational drug for muscular atrophy.
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TGF-βタイプIセリンスレオニンキナーザ受容体阻害剤による筋ジストロフィー治療法の開発(第2報)
使用TGF-β I型丝氨酸-苏氨酸激酶受体抑制剂治疗肌营养不良症的开发(第二次报告)
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[森田洋, 小平農, 加藤修明, 池田修一, Hanajima. R et al, 大澤裕]
通讯作者:
大澤裕
Hereditary sensory ataxic neuropathy associated with proximal muscle weakness in the lower extremities
与下肢近端肌无力相关的遗传性感觉共济失调神经病
DOI:
10.1016/j.jns.2009.12.011
发表时间:
2010
期刊:
J Neurol Sci
影响因子:
4.4
作者:
[Murakami T, Fukai Y, Rikimaru M, Henmi S, Ohsawa Y, Sunada Y.]
通讯作者:
Sunada Y.
Caveolin-3 regulates myostatin signaling.
Caveolin-3 调节肌肉生长抑制素信号传导。
DOI:
--
发表时间:
2008
期刊:
Mini-review. Acta Myol. 27
影响因子:
--
作者:
[Ohsawa Y, Okada T, Kuga A, Hayashi S, Murakami T, Tsuchida K, Noji S, Sunada Y]
通讯作者:
Sunada Y
筋ジストロフィーに対する抗myostatin治療薬の開発
开发治疗肌营养不良症的抗肌生长抑制素疗法
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[砂田芳秀, 大澤裕, 岡田只士, 西松伸一郎, 石崎雅俊, 菅智宏, 内野誠, 濃野勉, 野地澄晴, 土田邦博]
通讯作者:
土田邦博
caveolin-3欠損筋のdysferlin/myoferlin細胞内局在異常
Caveolin-3 缺陷肌肉中 Dysferlin/myoferlin 亚细胞定位异常
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[大澤裕, 岡田只士, 林紗織, 久我敦, 村上龍文, 若山吉弘, 澁谷誠二, 砂田芳秀]
通讯作者:
砂田芳秀
共 24 条
Continuous Query Algorithms for Moving Objects on LBS
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批准号:15K00147
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2015
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负责人:OHSAWA Yutaka
-
依托单位:
Study on Efficient Query Algorithms for Location Based Services
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批准号:24500107
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
-
财政年份:2012
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负责人:OHSAWA Yutaka
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依托单位:
Screening of muscle regenerative molecules for Duchenne muscular dystrophy
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批准号:23591261
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
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财政年份:2011
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负责人:OHSAWA Yutaka
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依托单位:
Continuous Monitoring of Moving Objects Based on Near-future Position Prediction
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批准号:21500093
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
-
财政年份:2009
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负责人:OHSAWA Yutaka
-
依托单位:
A Research on Structure of Geographic Information System based on Inplicit Topology Description Model
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批准号:12680407
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2000
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负责人:OHSAWA Yutaka
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依托单位:
Basic Study on Automatic Drawing Input System and Evaluation Method for Recognition Results
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批准号:05680310
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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负责人:OHSAWA Yutaka
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依托单位:
Study on a high-level processing for large size image using a effective geometrical graphic data structure
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批准号:61460233
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.58万
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财政年份:1986
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负责人:OHSAWA Yutaka
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依托单位:
海外基金