Mechanism of Insulin Sensitivity Regulation by the SUMO conjugating enzyme, Ubc9
Mechanism of Insulin Sensitivity Regulation by the SUMO conjugating enzyme, Ubc9
批准号:
20591046
负责人:
SHIBATA Hiroshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
In the present study, we showed that SUMO-conjugating enzyme Ubc9 regulates the insulin sensitivity of glucose transport via GLUT4 subcellular targeting and turnover in adipocytes. In addition, we showed that the retromer complex which is involved in the endosome-to-TGN transport plays an important role in the regulation of GLUT4 turnover.
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DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
インスリンによるレトロマー複合体の機能制御とGLUT4分解促進機構-酸化ストレスと細胞内トラフィックの接点-
胰岛素对retromer复合物的功能控制和GLUT4降解促进机制-氧化应激与细胞内交通之间的界面-
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[柴田宏, 他3名, 柴田宏]
通讯作者:
柴田宏
インスリンによるGLUT4ダウンレギュレーションにおけるプロテインキナーゼCK2の関与
蛋白激酶 CK2 参与胰岛素诱导的 GLUT4 下调
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[柴田宏, 他3名, 柴田宏, 柴田宏,小俣和香,長澤雅裕,中川祐子,小島至]
通讯作者:
柴田宏,小俣和香,長澤雅裕,中川祐子,小島至
インスリンによる活性酸素産生亢進を介したレトロマー機能の阻害とGLUT4分解促進
通过胰岛素增加活性氧产生抑制逆转录酶功能并促进 GLUT4 降解
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Furuta, A et al., 柴田宏,馬金輝,中川裕子,小島至, 馬金輝,長澤雅裕,中川祐子,小島至,柴田宏]
通讯作者:
馬金輝,長澤雅裕,中川祐子,小島至,柴田宏
The Role for the Retromer Complex in GLUT4 Trafficking and Degradation in Adipocytes
逆转录酶复合物在脂肪细胞 GLUT4 运输和降解中的作用
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Shibata H., Ma J., Nakagawa Y., Kodera T., Yoshida R., Kojima I.]
通讯作者:
Kojima I.
共 12 条
Mechanism of insulin-induced GLUT4 down-regulation through retromer inhibition
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批准号:23591295
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:SHIBATA Hiroshi
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依托单位:
A study of the SUMO-conjugating enzyme Ubc9 as a novel regulatory factor of insulin sensitivity
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批准号:18590974
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.53万
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财政年份:2006
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负责人:SHIBATA Hiroshi
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依托单位:
A novel mechanism of insulin sensitivity regulation by post-translational mechanisms
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批准号:16590867
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2004
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负责人:SHIBATA Hiroshi
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依托单位:
Study on related factors of maintaining productive activities in elderly people based on panel study
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批准号:16200045
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$14.14万
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财政年份:2004
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负责人:SHIBATA Hiroshi
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依托单位:
Cell Biological Dissection of GLUT4 Trafficking Pathways
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批准号:13671175
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2001
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负责人:SHIBATA Hiroshi
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依托单位:
Study on the vascular structure of esophagial varices using infrared fluorescent endoscopy
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批准号:12670492
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.22万
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财政年份:2000
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负责人:SHIBATA Hiroshi
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依托单位:
Dynamics of retirement, family and health
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批准号:12301013
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$21.04万
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财政年份:2000
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负责人:SHIBATA Hiroshi
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依托单位:
The mechanisms of insulin-regulated exocytosis of the GLUT4-containing vesicles
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批准号:11671107
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:SHIBATA Hiroshi
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依托单位:
Development of a cell-free system for study of insulin action
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批准号:10557102
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$5.57万
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财政年份:1998
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负责人:SHIBATA Hiroshi
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依托单位:
Study on the mechanism of insulin stimulation of glucose transport
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批准号:09671021
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:1997
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负责人:SHIBATA Hiroshi
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依托单位:
Recycling of glucose transporter and insulin action
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批准号:07671106
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1995
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负责人:SHIBATA Hiroshi
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依托单位:
Comprehensive study on falls and fractures in the community elderly in Japan.
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批准号:07307007
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$6.85万
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财政年份:1995
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负责人:SHIBATA Hiroshi
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依托单位:
Development of New Anti-diabetic Peptide Drug
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批准号:06557052
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项目类别:Grant-in-Aid for Developmental Scientific Research (B)
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资助金额:$4.54万
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财政年份:1994
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负责人:SHIBATA Hiroshi
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依托单位:
Study on the mechanism of insulin action on glucose transport
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批准号:05670837
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.28万
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财政年份:1993
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负责人:SHIBATA Hiroshi
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依托单位:
A ten - year comprehensive study of the community elderly
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批准号:61480175
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1986
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负责人:SHIBATA Hiroshi
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依托单位:
海外基金