Investigations of S1P receptors as novel therapeutic targets for metabolic syndrome

炎症性脂肪细胞因子分泌增加与代谢综合征的发病机制有关。目前的研究表明，鞘氨醇1-磷酸（S1 P）刺激炎症脂肪细胞因子的分泌，如IL-6和MCP-1从成熟的脂肪细胞，介导的受体S1 P的5个亚型中的S1 P3。S1 P3特异性抑制剂能有效抑制这些炎性脂肪细胞因子，这表明S1 P3特异性抑制剂可能改善代谢综合征的病理生理。

Increased secretion of inflammatory adipocytekines has been related to the pathogenesis of metabolic syndrome. Present study revealed that sphingosine 1-phosphate (S1P) stimulated inflammatory adipocytokine secretion such as IL-6 and MCP-1 from mature adipocytes, mediated by an receptor S1P3 among five subtype receptors for S1P. The specific inhibitor for S1P3 was effective to suppress these inflammatory adipocytokines, which suggest that the S1P3 specific inhibitor may ameliorate the pathophysiology of metabolic syndrome.