Effect of lipoprotein mediated by sphingosine-1 phosphate receptors and scavenger receptor class B type I

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HDL exerts a variety of anti-inflammatory and anti-atherogenic actions independently of the cholesterol metabolism. Here, we showed the cross-talk mechanism between statins and HDL in anti-inflammatory and anti-atherogenic actions, with a focus on scavenger receptor class B type I. Simvastatin treatment of HUVECs induces expression of SR-BI, which plays a critical role as a key molecule to enhance HDL-induced anti-inflammatory actions, including NOS activation and inhibition of adhesion molecule expression.