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Analyses on the mechanisms for cholesterol excretion from liver.

Analyses on the mechanisms for cholesterol excretion from liver.
肝脏排泄胆固醇的机制分析
批准号:
20591079
负责人:
TSUKAMOTO Kazuhisa
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
The liver is the only organ which excretes cholesterol from the body. The present study suggested 1) the existence of liver-specific sterolin which is important for excretion of cholesterol into the bile, and 2) that the cholesterol in the bile was re-absorbed with NPC1L1, which resulted in the production of apoE rich lipoproteins. Furthermore, it has been indicated that cholesterol in the liver, depending on its source, exerted distinct metabolic properties.
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会议论文
Modulation of, Lipoprotein and Glucose Metabolism with the Over-expression of Niemann-pick C1 Like 1 Protein (NPC1L1) In Mice Liver.
在小鼠肝脏中过表达 Niemann-pick C1 Like 1 蛋白 (NPC1L1) 来调节脂蛋白和葡萄糖代谢。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kurano M., Tsukamoto K., et al]
通讯作者: et al
HepG2スフェロイドのin vivtro脂質代謝研究における有用性
HepG2 球体在体内脂质代谢研究中的应用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [蔵野信、塚本和久, et al.]
通讯作者: et al.
DOI: 10.5551/jat.6999
发表时间: 2011-01-01
期刊: JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
影响因子: 4.4
作者: [Kurano, Makoto, Iso-O, Naoyuki, Tsukamoto, Kazuhisa]
通讯作者: Tsukamoto, Kazuhisa
LXR Agonist Increases ApoE Secretion from HepG2 Spheroid Together with Increased Production of VLDL and ApoE-Rich Large HDL.
LXR 激动剂可增加 HepG2 球体的 ApoE 分泌,同时增加 VLDL 和富含 ApoE 的大 HDL 的产生。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Kurano M., Tsukamoto K., et al]
通讯作者: et al
10
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    • 批准号:
      16K15330
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.25万
    • 财政年份:
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    • 负责人:
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    • 项目类别:
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      2014
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    • 批准号:
      23591333
    • 项目类别:
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    • 资助金额:
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    • 财政年份:
      2011
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    • 项目类别:
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    • 资助金额:
      $2.53万
    • 财政年份:
      2006
    • 负责人:
      TSUKAMOTO Kazuhisa
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    • 批准号:
      81000184
    • 项目类别:
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    • 资助金额:
      20.0万元
    • 批准年份:
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    • 负责人:
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    • 依托单位: