Modulation of endoplasmic reticulum stress by modification of cholesterol contents in liver.

增加肝脏胆固醇含量的途径有三条。在本研究中，腺病毒基因转移上调了这3条通路。所有这些途径均可增加肝脏胆固醇含量，但均不能诱导内质网应激。另一方面，三种途径都有改善血糖水平的作用，但不同途径改善血糖的分子机制不同。药物诱导和抑制内质网应激均可引起肝脏甘油三酯的蓄积。这些结果表明，肝脏内质网应激与糖脂代谢之间的关系并不是一帆风顺的。

There are three pathways which increase hepatic cholesterol contents. In this study, these 3 pathways have been up-regulated by adenoviral gene transfer. All these pathways increased the hepatic cholesterol contents; however, none did induce the ER stress. On the other hand, all three pathways caused the amelioration of blood glucose level; however, the molecular mechanisms underlying the amelioration of blood glucose were different among the pathways. Both the pharmacological induction and inhibition of ER stress evoked the accumulation of hepatic triglycerides. These results suggest that the association between hepatic ER stress and glucose and lipid metabolism would not be straightforward.