Modulation of endoplasmic reticulum stress by modification of cholesterol contents in liver.

有三种途径可以增加肝脏胆固醇含量。 在本研究中，这3个途径已经被腺病毒基因转移上调。 所有这些途径都增加了肝脏胆固醇含量，但是，没有一个诱导ER应激。 另一方面，所有三种途径都引起血糖水平的改善;然而，改善血糖的分子机制在这些途径之间是不同的。 ER应激的药理学诱导和抑制均引起肝甘油三酯的积累。 这些结果表明，肝脏内质网应激和糖脂代谢之间的联系并不简单。

There are three pathways which increase hepatic cholesterol contents. In this study, these 3 pathways have been up-regulated by adenoviral gene transfer. All these pathways increased the hepatic cholesterol contents; however, none did induce the ER stress. On the other hand, all three pathways caused the amelioration of blood glucose level; however, the molecular mechanisms underlying the amelioration of blood glucose were different among the pathways. Both the pharmacological induction and inhibition of ER stress evoked the accumulation of hepatic triglycerides. These results suggest that the association between hepatic ER stress and glucose and lipid metabolism would not be straightforward.