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Pathogenesis and treatment of small dense LDL metabolism in patients with coronary heart disease

Pathogenesis and treatment of small dense LDL metabolism in patients with coronary heart disease
冠心病患者小密LDL代谢的发病机制及治疗
批准号:
20591085
负责人:
HASHIMOTO Koichi
金额:
$3.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Dyslipidemia has been considered as a major risk factor for cardiovascular disease (CVD). LDL-centric treatment has failed to reduce CVD, thus highlighting other atherogenic lipoproteins. Among those, small dense LDL (sdLDL) is associated with postprandial lipemia. However, exact metabolism and treatment strategy of sdLDL is yet to be established. In the present study, we performed in vivo metabolic study using stable isotopically-labeled amino acid and found that rate of catabolism was 34% lower in sdLDL and this delayed catabolism was normalized by statin treatment.
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会议论文
Significant Regression of Left Ventricular Hypertrophy by ARB Valsartan assessd by Echocardiography
通过超声心动图评估 ARB 缬沙坦显着消退左心室肥厚
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hosoya T, et al., 岩崎泰正, Kanome T, Ikewaki K]
通讯作者: Ikewaki K
Kinetics of ApoB-containing Lipoproteins
含 ApoB 脂蛋白的动力学
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [T.Kusakabe, H.Tanioka, K.Ebihara, M.Hirata, L.Miyamoto, F.Miyanaga, H.Hige, D.Aotani, T.Fujisawa, H.Masuzaki, K.Hosoda, K.Nakao., Ikewaki K]
通讯作者: Ikewaki K
DOI: 10.1016/j.atherosclerosis.2010.07.024
发表时间: 2010-11-01
期刊: ATHEROSCLEROSIS
影响因子: 5.3
作者: [Nakaya, Kazuhiro, Ayaori, Makoto, Ikewaki, Katsunori]
通讯作者: Ikewaki, Katsunori
Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via LXRα/PPARγ pathway : findings from in vitro and ex vivo studies.
吡格列酮通过 LXRα/PPARγ 途径增加 ABCA1/ABCG1 表达,从而增强巨噬细胞的胆固醇流出:体外和离体研究的结果。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Takano K, Yasufuku-Takano J, et al., Ozasa H]
通讯作者: Ozasa H
15
    Empirical study of child care support "industry" - Quantitative and qualitative analysis by neo-institutionalism theory -
    • 批准号:
      15K13199
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.08万
    • 财政年份:
      2015
    • 负责人:
      HASHIMOTO Koichi
    • 依托单位:
    Construction of support system for local community-based investigator-initiated clinical study
    • 批准号:
      24659230
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      HASHIMOTO Koichi
    • 依托单位:
    analysis of the political process in the higher education field
    • 批准号:
      24653245
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.33万
    • 财政年份:
      2012
    • 负责人:
      HASHIMOTO Koichi
    • 依托单位:
    Automatic ROI Setting for Moving Nerons in Fluorescent Observation
    • 批准号:
      23650080
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2011
    • 负责人:
      HASHIMOTO Koichi
    • 依托单位:
    海外基金