Pathogenesis and treatment of small dense LDL metabolism in patients with coronary heart disease

冠心病患者小密LDL代谢的发病机制及治疗

• 批准号: 20591085
• 负责人: HASHIMOTO Koichi
• 金额: $ 3万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591085/
• 关键词: リポ蛋白; 安定同位体; LDL; small dense LDL; stable isotoPe; apoprotein; stable isotope

Dyslipidemia has been considered as a major risk factor for cardiovascular disease (CVD). LDL-centric treatment has failed to reduce CVD, thus highlighting other atherogenic lipoproteins. Among those, small dense LDL (sdLDL) is associated with postprandial lipemia. However, exact metabolism and treatment strategy of sdLDL is yet to be established. In the present study, we performed in vivo metabolic study using stable isotopically-labeled amino acid and found that rate of catabolism was 34% lower in sdLDL and this delayed catabolism was normalized by statin treatment.

血脂异常已被认为是心血管疾病（CVD）的主要危险因素。以LDL为中心的治疗未能降低CVD，因此突出了其他致动脉粥样硬化的脂蛋白。其中，小密度LDL（sdLDL）与餐后脂血症有关。然而，sdLDL的确切代谢和治疗策略尚未建立。在本研究中，我们使用稳定的同位素标记的氨基酸进行了体内代谢研究，发现sdLDL中的catenosis率降低了34%，并且这种延迟的catenosis通过他汀类药物治疗而正常化。

项目成果

Significant Regression of Left Ventricular Hypertrophy by ARB Valsartan assessd by Echocardiography

通过超声心动图评估 ARB 缬沙坦显着消退左心室肥厚

• 发表时间: 2010
• 作者: Hosoya T;et al.;岩崎泰正;Kanome T;Ikewaki K
• 通讯作者: Ikewaki K

Kinetics of ApoB-containing Lipoproteins

含 ApoB 脂蛋白的动力学

• 发表时间: 2009
• 作者: T.Kusakabe;H.Tanioka;K.Ebihara;M.Hirata;L.Miyamoto;F.Miyanaga;H.Hige;D.Aotani;T.Fujisawa;H.Masuzaki;K.Hosoda;K.Nakao.;Ikewaki K
• 通讯作者: Ikewaki K

Cilostazol enhances macrophage reverse cholesterol transport in vitro and in vivo

• DOI: 10.1016/j.atherosclerosis.2010.07.024
• 发表时间: 2010-11-01
• 期刊: ATHEROSCLEROSIS
• 影响因子: 5.3
• 作者: Nakaya, Kazuhiro;Ayaori, Makoto;Ikewaki, Katsunori
• 通讯作者: Ikewaki, Katsunori

Pioglitazone enhances cholesterol efflux from macrophages by increasing ABCA1/ABCG1 expressions via LXRα/PPARγ pathway : findings from in vitro and ex vivo studies.

吡格列酮通过 LXRα/PPARγ 途径增加 ABCA1/ABCG1 表达，从而增强巨噬细胞的胆固醇流出：体外和离体研究的结果。

• 发表时间: 2010
• 作者: Takano K;Yasufuku-Takano J;et al.;Ozasa H
• 通讯作者: Ozasa H

Coffee Consumption Enhances High-Density Lipoprotein-Mediated Cholesterol Efflux in Macrophages

• DOI: 10.1161/circresaha.109.206615
• 发表时间: 2010-03-05
• 期刊: CIRCULATION RESEARCH
• 影响因子: 20.1
• 作者: Uto-Kondo, Harumi;Ayaori, Makoto;Ikewaki, Katsunori
• 通讯作者: Ikewaki, Katsunori