Drug-resistant genes downstream of Polycomb group genes in leukemia stem cells

白血病干细胞中Polycomb组基因下游的耐药基因

• 批准号: 20591128
• 负责人: MIHARA Keichiro
• 金额: $ 3.08万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591128/
• 关键词: BMI-1; Survivin; MDR; survivin

Lymphoma (ML) cells transduced with BMI-1 obtained resistance to anti-cancer drugs. Survivin was enhanced in cell lines overexpressing BMI-1. Intriguingly, survivin mRNA was not induced in transduced cell lines, leading to the post-translational regulation involved. The expression of BMI-1 and survivin was much higher in chemotherapy-resistant samples than that in chemotherapy-sensitive.

用BMI-1转导的淋巴瘤（ML）细胞获得了对抗癌药物的抗性。Survivin在BMI-1过表达的细胞系中增强。有趣的是，生存素mRNA在转导的细胞系中不被诱导，导致涉及翻译后调节。化疗耐药组BMI-1和Survivin的表达明显高于化疗敏感组。

项目成果

Activated T-cell-mediated Immunotherapy With a Chimeric Receptor Against CD38 in B-cell Non-Hodgkin Lymphoma

• DOI: 10.1097/cji.0b013e3181adaff1
• 发表时间: 2009-09-01
• 期刊: JOURNAL OF IMMUNOTHERAPY
• 影响因子: 3.9
• 作者: Mihara, Keichiro;Yanagihara, Kazuyoshi;Kimura, Akiro
• 通讯作者: Kimura, Akiro

B細胞性リンパ腫におけるBMI-1の高発現はSurvivinの発現を促進し、抗癌剤耐性に関与する

B细胞淋巴瘤中BMI-1高表达促进Survivin表达并参与抗癌耐药

• 发表时间: 2010
• 作者: ジョイータ・バタチャリーヤ;三原圭一朗;大坪素秋;安永晋一郎;星正治;瀧原義宏;木村昭郎
• 通讯作者: 木村昭郎

Overexpression of BMI-1 is correlated with drug resistance in B-cell lymphomas through enhanced expression of survivin

BMI-1 的过度表达通过增强生存素的表达与 B 细胞淋巴瘤的耐药性相关

• 发表时间: 2010
• 作者: Joyeeta Bhattacharyya;et al
• 通讯作者: et al

高発現BMI-1はB細胞性悪性リンパ腫の抗癌剤耐性に関与している

高表达的BMI-1参与B细胞恶性淋巴瘤的抗癌耐药性

• 发表时间: 2010
• 作者: Ozaki S;Harada T;Fujii S;Nakamura S;Miki H;Nakano A;Kagawa K;Takeuchi K;Abe M;Matsumoto T.;Joyeeta Bhattacharyya
• 通讯作者: Joyeeta Bhattacharyya

Antitumor Effect of SN-38-Releasing Polymeric Micelles, NK012, on Spontaneous Peritoneal Metastases from Orthotopic Gastric Cancer in Mice Compared with Irinotecan

• DOI: 10.1158/0008-5472.can-08-2822
• 发表时间: 2008-11-15
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Nakajima, Takako Eguchi;Yanagihara, Kazuyoshi;Matsumura, Yasuhiro
• 通讯作者: Matsumura, Yasuhiro