Clinical Significance of Adipocytokines in Rheumatoid Arthritis

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Recent studies have demonstrated that adipocytokines secreted by adipocytes may have a role in the inflammatory process. We investigated their clinical significance in patients with rheumatoid arthritis (RA). We have reported that adiponectin stimulates the production of IL-8 (Biochem Biophys Res Commun. 2009 ; 378 : 218-223), and prostaglandin E2 (Arthritis Rheum. 2010 ; 62 : 1641-1649) by rheumatoid synovial fibroblasts in vitro. We also have reported that the serum levels of adiponectin, resistin, and leptin in RA patients were elevated (Intern Med. 2011 ; 50 : 269-275). These findings suggest that adipocytekines may, at least in part, contribute to synovial inflammation in RA.