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Adipokine network in systemic autoimmune diseases

Adipokine network in systemic autoimmune diseases
系统性自身免疫性疾病中的脂肪因子网络
批准号:
23591449
负责人:
KAWAI Shinichi
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Adipokines are molecules produced by adipose tissue. We have found that adiponectin, an adipokine stimulates inflammation in rheumatoid synovial fibroblasts. In this study, we measured serum adipokine concentrations in patients with systemic connective tissue diseases. We also conducted in vitro studies by primary cultures of rheumatoid synovial fibroblasts or peripheral blood mononuclear leukocytes. Not only pro-hyperglycemic but also anti-hyperglycemic adipokines showed a pro-inflammatory property in the patients with systemic connective tissue diseases. Further investigations will be needed to clarify the roles of adipokine network in pathogenesis of systemic autoimmune diseases.
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会议论文
Expression and function of chemerin in the synovial tissues of patients with rheumatoid arthritis
类风湿性关节炎患者滑膜组织中凯莫瑞的表达及功能
DOI: --
发表时间: 2013
期刊: J Med Soc Toho
影响因子: --
作者: [Kaburaki M, Kusunoki N, Takahashi H, Tsuchiya K, Kawai S, Endo H]
通讯作者: Endo H
DOI: 10.3109/14397595.2013.854074
发表时间: 2014-01-01
期刊: MODERN RHEUMATOLOGY
影响因子: 2.2
作者: [Takeuchi, Tsutomu, Kawai, Shinichi, Miyasaka, Nobuyuki]
通讯作者: Miyasaka, Nobuyuki
DOI: 10.1007/s10067-012-2082-5
发表时间: 2012-12
期刊: CLINICAL RHEUMATOLOGY
影响因子: 3.4
作者: [Imagawa, Tomoyuki, Takei, Syuji, Umebayashi, Hiroaki, Yamaguchi, Kenichi, Itoh, Yasuhiko, Kawai, Toshinao, Iwata, Naomi, Murata, Takuji, Okafuji, Ikuo, Miyoshi, Mari, Onoe, Yasuhiro, Kawano, Yoshifumi, Kinjo, Noriko, Mori, Masaaki, Mozaffarian, Neelufar, Kupper, Hartmut, Santra, Sourav, Patel, Gina, Kawai, Shinichi, Yokota, Shumpei]
通讯作者: Yokota, Shumpei
DOI: --
发表时间: 2013-04
期刊: Clinical and experimental rheumatology
影响因子: 3.7
作者: [S. Muraoka;N. Kusunoki;Hiroshi Takahashi;Kazuaki Tsuchiya;S. Kawai]
通讯作者: S. Muraoka;N. Kusunoki;Hiroshi Takahashi;Kazuaki Tsuchiya;S. Kawai
Pharmacogenetic study of methotrexate in patients with rheumatoid arthritis.
  • 批准号:
    26461477
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.16万
  • 财政年份:
    2014
  • 负责人:
    KAWAI Shinichi
  • 依托单位:
Interfirm division of labor and network in oversea business--Comparative analysis of Japanese and Chinese enterprises.
  • 批准号:
    20402033
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $10.65万
  • 财政年份:
    2008
  • 负责人:
    KAWAI Shinichi
  • 依托单位:
Clinical Significance of Adipocytokines in Rheumatoid Arthritis
  • 批准号:
    20591177
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.0万
  • 财政年份:
    2008
  • 负责人:
    KAWAI Shinichi
  • 依托单位:
Chinese economic internationalization : its interface and institutional change
  • 批准号:
    16252006
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
  • 资助金额:
    $16.47万
  • 财政年份:
    2004
  • 负责人:
    KAWAI Shinichi
  • 依托单位:
海外基金