The expression of high affinity IgE receptor β-chain in human mast cells and basophils, and its roles
The expression of high affinity IgE receptor β-chain in human mast cells and basophils, and its roles
批准号:
20591195
负责人:
OKAYAMA Yoshimichi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
The ratio of the FcεRIβ^+ cell number to the mast cell number was significantly increased in cases of atopic conjunctivitis, compared with non-allergic conjunctivitis. The diminution of FcεRIβ significantly down-regulated IgE-dependent mediator release, and the redistribution of Lyn to the cell membrane following IgE sensitization. Specific inhibition of the interaction between FcεRIβ and Lyn may represent a new therapeutic strategy for the treatment of human allergic diseases.
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Proteomic approach to FcεRI aggregation-initiated signal transduction cascade in human mast cells
人类肥大细胞中 FcεRI 聚集引发的信号转导级联的蛋白质组学方法
DOI:
--
发表时间:
2009
期刊:
Int Arch Allergy Immunol 149(Suppl.1)
影响因子:
--
作者:
[Martinez ME, Kiyono Y, Noriki S, Inai K, 他8名, Yamaoka K]
通讯作者:
Yamaoka K
高親和性IgE受容体beta鎖を分子標的としたアレルギー疾患の治療(シンポジウム3好塩基球・マスト細胞研究の進展とアレルギーの新展開)
以高亲和力IgE受体β链为分子靶点治疗过敏性疾病(研讨会3 嗜碱性粒细胞/肥大细胞研究进展及过敏新进展)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[岡山吉道]
通讯作者:
岡山吉道
IgE-dependent human mast cell degranulation is inhibited by intracellular introduction of phosphorylated FcεRI β immunoreceptor tyrosine-based activation motif.(Workshop 20. Mast cells in allergic responses)
通过在细胞内引入基于磷酸化 FcεRI β 免疫受体酪氨酸的激活基序来抑制 IgE 依赖性人肥大细胞脱颗粒。(研讨会 20. 过敏反应中的肥大细胞)
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Okayama Y, Matsuda A, Sasaki T, Nunomura S, Ra C]
通讯作者:
Ra C
新規ヒトマスト細胞活性化阻害ペプチド
新型人肥大细胞活化抑制肽
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Miyoshi T, Yamashita K, Arai T, Yamamoto K, Mizugishi K, Uchiyama T, 岡山吉道]
通讯作者:
岡山吉道
Intracellular introduction of phosphorylated FcεRI β immunoreceptor tyrosine-based activation motif inhibits IgE-dependent human mast cell activation.
细胞内引入磷酸化 FcεRI β 免疫受体酪氨酸激活基序可抑制 IgE 依赖性人肥大细胞激活。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Okayama Y, Ra C]
通讯作者:
Ra C
共 62 条
Elucidation of mastcell/basophil activation mechanism in chronic spontaneous urticaria
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批准号:20K08811
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2020
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负责人:OKAYAMA Yoshimichi
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依托单位:
Treatment strategy of allergy and immunological diseases against MrgX2 expressed on human mast cells as a target molecule for the treatment
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批准号:15K09558
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.08万
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财政年份:2015
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负责人:OKAYAMA Yoshimichi
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依托单位:
Investigation of mechanisms of human mast cell activation by respiratory syncytial virus (RSV) and human rhinovirus (HRV) and involvement of asthma inception by these viruses
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批准号:23591470
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2011
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负责人:OKAYAMA Yoshimichi
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依托单位:
IgE-dependent TSLP production by human mast cells and the role of mast cell-derived TSLP in bronchial asthma
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批准号:18604009
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.64万
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财政年份:2006
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负责人:OKAYAMA Yoshimichi
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依托单位:
Investigation of human mast cell biological function induced by FcγRI aggregation
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批准号:14570402
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2002
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负责人:OKAYAMA Yoshimichi
-
依托单位:
海外基金